psychiatryПСИХИАТРИЯPsychiatry (Moscow) (Psikhiatriya)1683-83192618-6667FSBSI “The Mental Health Research Centre”; LLC «Publisher «MIA»10.30629/2618-6667-2023-21-7-24-30psychiatry-1081Research ArticleПСИХОПАТОЛОГИЯ, КЛИНИЧЕСКАЯ И БИОЛОГИЧЕСКАЯ ПСИХИАТРИЯPSYCHOPATHOLOGY, CLINICAL AND BIOLOGICAL PSYCHIATRYСтруктурно-анатомические особенности головного мозга у больных шизотипическим расстройством с симптомами кататонии: пилотное исследованиеAnatomo-Morphological Brain Featuresi in Patients with Schizotypal Disorder with Catatoniс Symptoms: A Pilot Studyhttps://orcid.org/0000-0002-0649-6663ЛебедеваИ. С.LebedevaI. S.

Ирина Сергеевна Лебедева, доктор биологических наук, профессор, заведующий лабораторией, лаборатория нейровизуализации и мультимодального анализа

Москва

Irina S. Lebedeva, Dr. of Sci. (Biol.), Professor, Head of Laboratory, Laboratory of Neuroimaging and Multimodal Analysis

Moscow

irina.lebedeva@ncpz.ruhttps://orcid.org/0000-0001-6688-4329ТомышевА. С.TomyshevA. S.

Александр Сергеевич Томышев, научный сотрудник, лаборатория нейровизуализации и мультимодального анализа

Москва

Alexander S. Tomyshev, Researcher, Laboratory of Neuroimaging and Multimodal Analysis

Moscow

alexander.tomyshev@gmail.comhttps://orcid.org/0000-0002-6563-9169БорисоваП. О.BorisovaP. O.

Полина Олеговна Борисова, кандидат медицинских наук, научный сотрудник, отдел по изучению пограничной психической патологии и психосоматических расстройств

Москва

Polina O. Borisova, Cand. of Sci. (Med.), Researcher, Department of Borderline Mental Pathology and Psychosomatic Disorders

Moscow

bori.pauline@gmail.comhttps://orcid.org/0000-0002-1822-8973РомановД. В.RomanovD. V.

Дмитрий Владимирович Романов, ведущий научный сотрудник, отдел по изучению пограничной психической патологии и психосоматических расстройств; доктор медицинских наук, доцент, профессор, кафедра психиатрии и психосоматики

Москва

Dmitry V. Romanov, Dr. of Sci. (Med.), Department of Borderline Mental Pathology and Psychosomatic Disorders; Docent, Professor, Leading Researcher, Psychiatry and Psychosomatics Department

Moscow

newt777@mail.ruФГБНУ «Научный центр психического здоровья»РоссияFSBSI “Mental Health Research Centre”Russian FederationФГБНУ «Научный центр психического здоровья»; ИКМ ФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияFSBSI “Mental Health Research Centre”; Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2023300120242172430Copyright © Лебедева И.С., Томышев А.С., Борисова П.О., Романов Д.В., 20242024Лебедева И.С., Томышев А.С., Борисова П.О., Романов Д.В.Lebedeva I.S., Tomyshev A.S., Borisova P.O., Romanov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journalpsychiatry.com/jour/article/view/1081

Обоснование: особенности структурных характеристик головного мозга при психических заболеваниях являются значимыми нейробиологическими показателями как для понимания патогенеза заболеваний, так и для обнаружения потенциально валидных прогностических маркеров. Цель пилотного исследования: определить спектр морфометрических параметров головного мозга у больных шизотипическим расстройством с симптомами кататонии. Пациенты и методы: в исследование включены 33 пациента и 33 психически здоровых лица, подобранные по полу и возрасту. Испытуемым проводили структурную МРТ высокого разрешения на томографе 3Т Philips Ingenia. Результаты: у пациентов толщина серого вещества в ряде областей коры оказалась меньше, чем у здоровых лиц из группы контроля. В спектре морфометрических показателей особое внимание привлекли ранее не отмеченные в литературе по шизотипическому расстройству изменения прецентральной извилины, области первичной моторной коры. Помимо этого, были обнаружены меньшие объемы прилежащих ядер, структур, включенных в процессы выбора действий. Выводы: проведенное пилотное исследование позволило выявить при шизотипическом расстройстве отдельные элементы мозговой мозаики, предположительно ассоциированные с синдромом кататонии.

Background: brain structural peculiarities in different mental disorders are neurobiological indicators that are extremely important both for understanding of the diseases’ pathogenesis and for identifying potentially valid prognostic markers. The aim of this pilot study was to identify the range of brain morphometric parameters in the group of patients with schizotypal disorders with catatonia syndrome. Patients and methods: 33 patients with schizotypal disorder and 33 age-matched mentally healthy subjects underwent high-resolution structural MRI on a 3T Philips Ingenia scanner. Results: there were found widely distributed intergroup differences in form of the smaller gray matter thickness. In this spectrum, a morphometric abnormality of the precentral gyrus, an area of the primary motor cortex localization, previously not noted in the literature on schizotypal disorder, drew special attention. In addition, smaller volume of the nuclei accumbens (included in the processes of choosing actions) was found. Conclusions: this pilot study allowed to reveal some brain elements of the mosaic presumably associated with the manifestation of catatonia syndrome in schizotypal disorder.

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The authors declare that there are no conflicts of interest present.