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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">psychiatry</journal-id><journal-title-group><journal-title xml:lang="ru">ПСИХИАТРИЯ</journal-title><trans-title-group xml:lang="en"><trans-title>Psychiatry (Moscow) (Psikhiatriya)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-8319</issn><issn pub-type="epub">2618-6667</issn><publisher><publisher-name>FSBSI “The Mental Health Research Centre”;   LLC «Publisher «MIA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2618-6667-2024-22-6-72-81</article-id><article-id custom-type="elpub" pub-id-type="custom">psychiatry-1281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПСИХОПАТОЛОГИЯ, КЛИНИЧЕСКАЯ И БИОЛОГИЧЕСКАЯ ПСИХИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PSYCHOPATHOLOGY, CLINICAL AND BIOLOGICAL PSYCHIATRY</subject></subj-group></article-categories><title-group><article-title>Нелеченный психоз в анамнезе: влияние на прогноз параноидной шизофрении. Клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>History of Untreated Psychosis: the Impact on Prognosis of Paranoid Schizophrenia. Case Report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3471-5293</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чинарев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chinarev</surname><given-names>V. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виталий Александрович Чинарев, ассистент, кафедра психиатрии; заведующий отделением первого психотического эпизода</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Vitaly A. Chinarev, Assistant Professor, Department of Psychiatry; Head of Psychiatric unit of the rst episode</p><p> Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5811-4428</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малинина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malinina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Викторовна Малинина, доктор медицинских наук, профессор, заведующий кафедрой психиатрии</p><p>Челябинск</p><p>Scopus ID: 36700078600</p></bio><bio xml:lang="en"><p>Elena V. Malinina, Dr. Sci. (Med.), Professor, Head of Psychiatry Department</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Обухова</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Obukhova</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Дмитриевна Обухова, студентка</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Maria D. Obukhova, student</p><p>Chelyabinsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет Минздрава России»; ГБУЗ ОКСПНБ № 1 г. Челябинска</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University of Russian Federation Ministry of Health; GBUZ OKSPNB No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет Минздрава России»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University of Russian Federation Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>24</day><month>02</month><year>2025</year></pub-date><volume>22</volume><issue>6</issue><fpage>72</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чинарев В.А., Малинина Е.В., Обухова М.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Чинарев В.А., Малинина Е.В., Обухова М.Д.</copyright-holder><copyright-holder xml:lang="en">Chinarev V.А., Malinina E.V., Obukhova M.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journalpsychiatry.com/jour/article/view/1281">https://www.journalpsychiatry.com/jour/article/view/1281</self-uri><abstract><p>Обоснование: в практике врачей-психиатров встречаются случаи, когда длительный период отсутствия адекватной антипсихотической терапии расстройств шизофренического спектра (РШС) приводит к непредвиденным последствиям в отношении динамики заболевания в дальнейшем. Актуальность данной проблемы обоснована большим количеством клинических и статистических наблюдений, демонстрирующих высокую распространенность этих расстройств среди пациентов психиатрических больниц. Особенности течения болезни в зависимости от длительности периода нелеченного психоза имеют научное и практическое значение, влияя на эффективность поздно начатой терапии, на долгосрочные результаты лечения, а также на качество и сроки ремиссии. Цель исследования — на примере клинического случая с длительным периодом нелеченного психоза оценить эффективность актуального лечения, степень редукции психотической симптоматики и прогноз параноидной шизофрении. Пациент и методы: клинико-психопатологический, клинико-динамический методы исследования использовали для изучения клинических проявлений заболевания у пациента с парафренным синдромом и дефицитарной симптоматикой в рамках непрерывного типа течения параноидной шизофрении. Результаты: представленный клинический случай иллюстрирует проблему неблагоприятного прогноза продолжительного периода нелеченного психотического состояния. Выбор актуальной терапии состоял в комбинации типичных антипсихотических препаратов первого поколения и клозапина. Заключение: рассмотренное клиническое наблюдение подтверждает важность своевременного начала адекватной терапии при первом психотическом эпизоде. Длительный период нелеченного психоза негативно влияет на эффективность психофармакотерапии и исход заболевания. </p></abstract><trans-abstract xml:lang="en"><p>Background: psychiatrists often face difficulties in selecting appropriate psychopharmacological treatments when patients with Schizophrenia spectrum disorders have been without adequate antipsychotic medication for a long period. This can lead to unforeseen complications and difficulties in case managing. The relevance of this issue is highlighted by numerous clinical and statistical studies that demonstrate the high prevalence of these disorders among psychiatric hospital patients. Additionally, the course of the illness can vary depending on untreated period duration, which has important scientific and practical implications for long-term treatment outcomes, therapy effectiveness, and the timing and quality of remissions. The aim: using a case report as an example to evaluate the impact of long-term nontreatment, we will look at the degree of improvement in psychotic symptoms and the prognosis for paranoid schizophrenia after a long period of untreated psychosis. Patient and Methods: clinicalpsychopathological and clinical-dynamic methods were used to study the clinical manifestations in a patient with paranoid syndrome and deficit symptoms, within the context of a continuous form of paranoid schizophrenia, against the background of a prolonged period of untreated psychosis. Results: the presented clinical case highlights the issue of a poor prognosis after a long period of untreated psychosis. The treatment plan consisted of a combination of traditional first-generation antipsychotics and clozapine, which has been shown to be highly effective and safe in treating paraphrenia in schizophrenia. Conclusion: the clinical observation in question emphasized the significance of timely and appropriate initiation of treatment at the onset of first psychotic episode. Long period of untreated psychosis have been shown to negatively impact the effectiveness of psychopharmacological therapy and the overall outcome of the illness.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>параноидная шизофрения</kwd><kwd>период нелеченного психоза</kwd><kwd>первый психотический эпизод</kwd><kwd>парафренный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>paranoid schizophrenia</kwd><kwd>period of untreated psychosis</kwd><kwd>first psychotic episode</kwd><kwd>paraphrenic syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Williams R, Ostinelli EG, Agorinya J, Minichino A, De Crescenzo F, Maughan D, Puntis S, Cliffe C, Kurtulmus A, Lennox BR, Cipriani A. Comparing interventions for early psychosis: a systematic review and component network meta-analysis. EClinicalMedicine. 2024 Mar 14;70:102537. doi: 10.1016/j.eclinm.2024.102537. 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