<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">psychiatry</journal-id><journal-title-group><journal-title xml:lang="ru">ПСИХИАТРИЯ</journal-title><trans-title-group xml:lang="en"><trans-title>Psychiatry (Moscow) (Psikhiatriya)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-8319</issn><issn pub-type="epub">2618-6667</issn><publisher><publisher-name>FSBSI “The Mental Health Research Centre”;   LLC «Publisher «MIA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2618-6667-2025-23-6-132-136</article-id><article-id custom-type="elpub" pub-id-type="custom">psychiatry-1484</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФОРМАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFORMATION</subject></subj-group></article-categories><title-group><article-title>Опыт использования фонда коллекций биоматериала «НейроРесурс» для решения фундаментальных и прикладных задач в неврологии и психиатрии</article-title><trans-title-group xml:lang="en"><trans-title>The Use of the Biomaterial Collections Fund “NeuroResource” to Solve Fundamental and Applied Problems in Neurology and Psychiatry</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3927-9286</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Semina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Владимировна Семина, доктор биологических наук, заместитель директора по научно-проектной деятельности, научный руководитель, Институт биологической психиатрии, ФГБНУ НЦПЗ</p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina V. Semina, Dr. Sci. (Biol.), Deputy Director for Research and Project Activities, Head of Science, Institute of Biological Psychiatry, Mental Health Research Centre, Moscow Russia; Professor, Department of Public Health and Healthcare, Immanuel Kant Baltic Federal University</p><p>Kaliningrad</p></bio><email xlink:type="simple">e-semina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4134-8367</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юров</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Iourov</surname><given-names>I. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иван Юрьевич Юров, доктор биологических наук, профессор, член-корреспондент РАН, заведующий лабораторией молекулярной генетики и цитогеномики мозга имени профессора Ю.Б. Юрова, ФГБНУ НЦПЗ; заведующий лабораторией молекулярной цитогенетики нервно-психических заболеваний имени профессора С.Г. Ворсановой, «НИКИ педиатрии и детской хирургии имени академика Ю.Е. Вельтищева», ФГАОУ ВО РНИМУ им. Н.И. Пирогова</p><p>Москва</p></bio><bio xml:lang="en"><p>Ivan Y. Iourov, Dr, Sci (Biol.), Professor, Corresponding member of RAS, Head of Lab of Molecular Genetics and Brain Cytogenomics named after prof. Yu.B. Yurov; Mental Health Research Centre, Head of Lab of Molecular Cytogenetics of Neuropsychiatric Disorders named after prof. E.G. Vorsanjva, Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University</p><p>Moscow</p></bio><email xlink:type="simple">ivan.iourov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5390-6007</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зозуля</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zozulya</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Александровна Зозуля, кандидат биологических наук, заведующий лабораторией, лаборатория нейроиммунологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana A. Zozulya, Cand. Sci. (Biol.), Head of Laboratory, Neuroimmunology Laboratory</p><p>Moscow</p></bio><email xlink:type="simple">s.ermakova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7182-2472</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чайка</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chaika</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Александровна Чайка, доктор медицинских наук, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Yulia A. Chaika, Dr. Sci. (Med.), Director</p><p>Moscow</p></bio><email xlink:type="simple">berseneva76@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9960-7114</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голимбет</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Golimbet</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вера Евгеньевна Голимбет, доктор биологических наук, профессор, заведующий лабораторией, лаборатория клинической генетики</p><p>Москва</p></bio><bio xml:lang="en"><p>Vera E. Golimbet, Dr Sci. (Biol.), Professor, Head of Clinical Genetics Laboratory</p><p>Moscow</p></bio><email xlink:type="simple">golimbet@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр психического здоровья»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBSI Mental Health Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2026</year></pub-date><volume>23</volume><issue>6</issue><fpage>132</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Семина Е.В., Юров И.Ю., Зозуля С.А., Чайка Ю.А., Голимбет В.Е., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Семина Е.В., Юров И.Ю., Зозуля С.А., Чайка Ю.А., Голимбет В.Е.</copyright-holder><copyright-holder xml:lang="en">Semina E.V., Iourov I.Y., Zozulya S.A., Chaika Y.A., Golimbet V.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journalpsychiatry.com/jour/article/view/1484">https://www.journalpsychiatry.com/jour/article/view/1484</self-uri><abstract><p>Современные достижения в области геномики, протеомики и клеточных технологий открыли новые возможности для изучения патофизиологических основ психических и неврологических заболеваний. Ключевым элементом для таких исследований являются хорошо охарактеризованные коллекции биоматериала, ассоциированные с детальными клиническими данными. Создание таких ресурсов позволяет перейти к решению задач персонализированной медицины, включая поиск биомаркеров диагностики, прогноза и эффективности терапии. В данном сообщении мы представляем опыт создания и использования Фонда коллекций биоматериала «НейроРесурс», созданного и зарегистрированного на базе ФГБНУ «Научный центр психического здоровья».</p></abstract><trans-abstract xml:lang="en"><p>Modern advances in genomics, proteomics, and cell technologies have opened up new opportunities for studying the pathophysiological foundations of mental and neurological disorders. A key element for such research is well-characterized biomaterial collections associated with detailed clinical data. The creation of such resources allows for the advancement of personalized medicine, including the search for biomarkers for diagnostics, prognosis, and treatment efficacy. In this paper, we present the experience of creating and using the Biomaterial Collections Fund “NeuroResource” registered at the Mental Health Research Center.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>«НейроРесурс»</kwd><kwd>биобанк</kwd><kwd>биоколлекция</kwd><kwd>психические расстройства</kwd><kwd>биомаркеры</kwd><kwd>генетика</kwd><kwd>персонализированная психиатрия</kwd><kwd>нейробиология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>NeuroResource</kwd><kwd>biobank</kwd><kwd>biocollection</kwd><kwd>mental disorders</kwd><kwd>biomarkers</kwd><kwd>genetics</kwd><kwd>personalized psychiatry</kwd><kwd>neurobiology</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при поддержке Министерства науки и высшего образования Российской Федерации в рамках государственного задания (Федеральная научно-техническая программа развития генетических технологий на 2019–2030 годы, Соглашение № 075-15-2025-474 от 29.05.2025). Авторы выражают благодарность всем сотрудникам ФГБНУ НЦПЗ, участвовавшим в формировании коллекции, а также пациентам и их семьям.</funding-statement><funding-statement xml:lang="en">This work was supported by the Ministry of Science and Higher Education of the Russian Federation (the Federal Scientific-technical program for genetic technologies development for 2019–2030, agreement № 075-15-2025-474 of 29.05.2025). The authors thank all collaborators of Mental Health Research Centre taking part in collection creation, and patients and their family members.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rees E, Han J, Morgan J, Carrera N, Escott-Price V, Pocklington AJ, Duffield M, Hall LS, Legge SE, Pardiñas AF, Richards AL, Roth J, Lezheiko T, Kondratyev N, Kaleda V, Golimbet V, Parellada M, González-Peñas J, Arango C; GROUP Investigators; Gawlik M, Kirov G, Walters JTR, Holmans P, O'Donovan MC, Owen MJ. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nat Neurosci. 2020;3(2):179. doi: 10.1038/s41593-019-0565-2</mixed-citation><mixed-citation xml:lang="en">Rees E, Han J, Morgan J, Carrera N, Escott-Price V, Pocklington AJ, Dufeld M, Hall LS, Legge SE, Pardiñas AF, Richards AL, Roth J, Lezheiko T, Kondratyev N, Kaleda V, Golimbet V, Parellada M, González-Peñas J, Arango C; GROUP Investigators; Gawlik M, Kirov G, Walters JTR, Holmans P, O'Donovan MC, Owen MJ. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nat Neurosci. 2020;3(2):179. doi: 10.1038/s41593-019-0565-2</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kondratyev NV, Alfimova MV, Kaleda VG, Lezheiko TV, Mikhailova VA, Karpov DS, Ublinsky MV, Ushakov VL, Lebedeva IS, Golimbet VE. Assessing the impact of the de novo SLC6A1 mutation in schizophrenia through a comprehensive case study. Psychiatry Res. 2023;327:115399. doi: 10.1016/j.psychres.2023.115399</mixed-citation><mixed-citation xml:lang="en">Kondratyev NV, Alfimova MV, Kaleda VG, Lezheiko TV, Mikhailova VA, Karpov DS, Ublinsky MV, Ushakov VL, Lebedeva IS, Golimbet VE. Assessing the impact of the de novo SLC6A1 mutation in schizophrenia through a comprehensive case study. Psychiatry Res. 2023;327:115399. doi: 10.1016/j.psychres.2023.115399</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA; Genetic Risk and Outcome in Psychosis (GROUP); Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA. Common variants conferring risk of schizophrenia. Nature. 2009;460(7256):744. doi: 10.1038/nature08186</mixed-citation><mixed-citation xml:lang="en">Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA; Genetic Risk and Outcome in Psychosis (GROUP); Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA. Common variants conferring risk of schizophrenia. Nature. 2009;460(7256):744. doi: 10.1038/nature08186</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, Bergen SE, Collins AL, Crowley JJ, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray NR, Xia K, Bettella F, Borglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, Durmishi N, Gill M, Golimbet V, Hamshere ML, Holmans P, Hougaard DM, Kendler KS, Lin K, Morris DW, Mors O, Mortensen PB, Neale BM, O'Neill FA, Owen MJ, Milovancevic MP, Posthuma D, Powell J, Richards AL, Riley BP, Ruderfer D, Rujescu D, Sigurdsson E, Silagadze T, Smit AB, Stefansson H, Steinberg S, Suvisaari J, Tosato S, Verhage M, Walters JT; Multicenter Genetic Studies of Schizophrenia Consortium; Levinson DF, Gejman PV, Kendler KS, Laurent C, Mowry BJ, O'Donovan MC, Owen MJ, Pulver AE, Riley BP, Schwab SG, Wildenauer DB, Dudbridge F, Holmans P, Shi J, Albus M, Alexander M, Campion D, Cohen D, Dikeos D, Duan J, Eichhammer P, Godard S, Hansen M, Lerer FB, Liang KY, Maier W, Mallet J, Nertney DA, Nestadt G, Norton N, O'Neill FA, Papadimitriou GN, Ribble R, Sanders AR, Silverman JM, Walsh D, Williams NM, Wormley B; Psychosis Endophenotypes International Consortium; Arranz MJ, Bakker S, Bender S, Bramon E, Collier D. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45(10):1150–9. doi: 10.1038/ng.2742</mixed-citation><mixed-citation xml:lang="en">Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, Bergen SE, Collins AL, Crowley JJ, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray NR, Xia K, Bettella F, Borglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, Durmishi N, Gill M, Golimbet V, Hamshere ML, Holmans P, Hougaard DM, Kendler KS, Lin K, Morris DW, Mors O, Mortensen PB, Neale BM, O'Neill FA, Owen MJ, Milovancevic MP, Posthuma D, Powell J, Richards AL, Riley BP, Ruderfer D, Rujescu D, Sigurdsson E, Silagadze T, Smit AB, Stefansson H, Steinberg S, Suvisaari J, Tosato S, Verhage M, Walters JT; Multicenter Genetic Studies of Schizophrenia Consortium; Levinson DF, Gejman PV, Kendler KS, Laurent C, Mowry BJ, O'Donovan MC, Owen MJ, Pulver AE, Riley BP, Schwab SG, Wildenauer DB, Dudbridge F, Holmans P, Shi J, Albus M, Alexander M, Campion D, Cohen D, Dikeos D, Duan J, Eichhammer P, Godard S, Hansen M, Lerer FB, Liang KY, Maier W, Mallet J, Nertney DA, Nestadt G, Norton N, O'Neill FA, Papadimitriou GN, Ribble R, Sanders AR, Silverman JM, Walsh D, Williams NM, Wormley B; Psychosis Endophenotypes International Consortium; Arranz MJ, Bakker S, Bender S, Bramon E, Collier D. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45(10):1150–9. doi: 10.1038/ng.2742</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T; GERAD1 Consortium; CRESTAR Consortium; Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018;50(3):381. doi: 10.1038/s41588-018-0059-2</mixed-citation><mixed-citation xml:lang="en">Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T; GERAD1 Consortium; CRESTAR Consortium; Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018;50(3):381. doi: 10.1038/s41588-018-0059-2</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo MH, Bacanu SA, Bass NJ, Begemann M, Belliveau RA, Bene J, Benyamin B, Bergen SE, Blasi G, Bobes J, Bonassi S, Braun A, Bressan RA, Bromet EJ, Bruggeman R, Buckley PF, Buckner RL, Bybjerg-Grauholm J, Cahn W, Cairns MJ, Calkins ME, Carr VJ, Castle D, Catts SV, Chambert KD, Chan RCK, Chaumette B, Cheng W, Cheung EFC, Chong SA, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis KL, de Haan L, Degenhardt F, DeLisi LE, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson JG, Fañanás L, Faraone SV, Fiorentino A, Forstner A, Frank J, Freimer NB, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon ES, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, González Peñas J, González-Pinto A. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604(7906):502. doi: 10.1038/s41586-022-04434-5</mixed-citation><mixed-citation xml:lang="en">Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo MH, Bacanu SA, Bass NJ, Begemann M, Belliveau RA, Bene J, Benyamin B, Bergen SE, Blasi G, Bobes J, Bonassi S, Braun A, Bressan RA, Bromet EJ, Bruggeman R, Buckley PF, Buckner RL, Bybjerg-Grauholm J, Cahn W, Cairns MJ, Calkins ME, Carr VJ, Castle D, Catts SV, Chambert KD, Chan RCK, Chaumette B, Cheng W, Cheung EFC, Chong SA, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis KL, de Haan L, Degenhardt F, DeLisi LE, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson JG, Fañanás L, Faraone SV, Fiorentino A, Forstner A, Frank J, Freimer NB, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon ES, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, González Peñas J, González-Pinto A. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604(7906):502. doi: 10.1038/s41586-022-04434-5</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Alfimova M, Gabaeva M, Lezheiko T, Plakunova V, Chaika Y, Golimbet V. Demographic, Premorbid, and Clinical Characteristics of Schizophrenia Spectrum Patients with High and Low Polygenic Liability to the Disorder. Diseases. 2025;13(3):66. doi: 10.3390/diseases13030066</mixed-citation><mixed-citation xml:lang="en">Alfimova M, Gabaeva M, Lezheiko T, Plakunova V, Chaika Y, Golimbet V. Demographic, Premorbid, and Clinical Characteristics of Schizophrenia Spectrum Patients with High and Low Polygenic Liability to the Disorder. Diseases. 2025;13(3):66. doi: 10.3390/diseases13030066</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Клюшник ТП, Смулевич АБ, Голимбет ВЕ, Зозуля СА, Воронова ЕИ. К созданию клинико-биологической концепции шизофрении: соучастие хронического воспаления и генетической предиспозиции в формировании психопатологических расстройств. Психиатрия. 2022;20(2):6–13. doi: 30629/2618-6667-2022-20-2-6-13</mixed-citation><mixed-citation xml:lang="en">Klyushnik TP, Smulevich AB, Golimbet VE, Zozulya SA, Voronova YeI. Towards the creation of a clinical and biological concept of schizophrenia: the complicity of chronic inflammation and genetic predisposition in the formation of psychopathological disorders. Psychiatry (Moscow) (Psikhiatriya). 2022;20(2):6–13. (In Russ.). doi: 30629/2618-6667-2022-20-2-6-13</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Андросова ЛВ, Симонов АН, Сенько ОВ, Михайлова НМ, Кузнецова АВ, Клюшник ТП. Диагностика и оценка тяжести болезни Альцгеймера: алгоритмы машинного обучения на основе маркеров воспаления. Психиатрия. 2024;22(1):6–14. doi: 10.30629/2618-6667-2024-22-1-6-14</mixed-citation><mixed-citation xml:lang="en">Androsova LV, Simonov AN, Senko OV, Mikhaylova NM, Kuznetsova AV, Klyushnik TP. Diagnostics and Assessment of the Severity of Alzheimer's Disease: Machine Learning Algorithms Based on Markers of Inflammation. Psychiatry (Moscow) (Psikhiatriya). 2024;22(1):6–14. (In Russ.). doi: 10.30629/2618-6667-2024-22-1-6-14</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zelenova EA, Kondratyev NV, Lezheiko TV, Tsarapkin GY, Kryukov AI, Kishinevsky AE, Tovmasyan AS, Momotyuk ED, Dashinimaev EB, Golimbet VE. Characterisation of Neurospheres-Derived Cells from Human Olfactory Epithelium. Cells. 2021;10(7):1690. doi: 10.3390/cells10071690</mixed-citation><mixed-citation xml:lang="en">Zelenova EA, Kondratyev NV, Lezheiko TV, Tsarapkin GY, Kryukov AI, Kishinevsky AE, Tovmasyan AS, Momotyuk ED, Dashinimaev EB, Golimbet VE. Characterisation of Neurospheres-Derived Cells from Human Olfactory Epithelium. Cells. 2021;10(7):1690. doi: 10.3390/cells10071690</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Iourov IY, Vorsanova SG, Yurov YB, Zelenova MA, Kurinnaia OS, Vasin KS, Kutsev SI. The cytogenomic “theory of everything”: chromohelkosis may underlie chromosomal instability and mosaicism in disease and aging. Int J Mol Sci. 2020;21(21):8328. doi: 10.3390/ijms21218328</mixed-citation><mixed-citation xml:lang="en">Iourov IY, Vorsanova SG, Yurov YB, Zelenova MA, Kurinnaia OS, Vasin KS, Kutsev SI. The cytogenomic “theory of everything”: chromohelkosis may underlie chromosomal instability and mosaicism in disease and aging. Int J Mol Sci. 2020;21(21):8328. doi: 10.3390/ijms21218328</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Iourov IY, Yurov YB, Vorsanova SG, Kutsev SI. Chromosome instability, aging and brain diseases. Cells. 2021;10(5):1256. doi: 10.3390/cells10051256</mixed-citation><mixed-citation xml:lang="en">Iourov IY, Yurov YB, Vorsanova SG, Kutsev SI. Chromosome instability, aging and brain diseases. Cells. 2021;10(5):1256. doi: 10.3390/cells10051256</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Iourov IY, Vorsanova SG, Kurinnaia OS, Zelenova MA, Vasin KS, Demidova IA, Kolotii AD, Kravets VS, Iuditskaia ME, Iakushev NS, Soloviev IV, Yurov YB. Molecular cytogenetic and cytopostgenomic analysis of the human genome. Res Results Biomed. 2022;8(4):412– 423. doi: 10.18413/2658-6533-2022-8-4-0-1</mixed-citation><mixed-citation xml:lang="en">Iourov IY, Vorsanova SG, Kurinnaia OS, Zelenova MA, Vasin KS, Demidova IA, Kolotii AD, Kravets VS, Iuditskaia ME, Iakushev NS, Soloviev IV, Yurov YB. Molecular cytogenetic and cytopostgenomic analysis of the human genome. Res Results Biomed. 2022;8(4):412– 423. doi: 10.18413/2658-6533-2022-8-4-0-1</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
