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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">psychiatry</journal-id><journal-title-group><journal-title xml:lang="ru">ПСИХИАТРИЯ</journal-title><trans-title-group xml:lang="en"><trans-title>Psychiatry (Moscow) (Psikhiatriya)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-8319</issn><issn pub-type="epub">2618-6667</issn><publisher><publisher-name>FSBSI “The Mental Health Research Centre”;   LLC «Publisher «MIA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2618-6667-2019-17-3-87-97</article-id><article-id custom-type="elpub" pub-id-type="custom">psychiatry-419</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS</subject></subj-group></article-categories><title-group><article-title>Депрессивные расстройства в позднем возрасте: особенности клиники и течения</article-title><trans-title-group xml:lang="en"><trans-title>Depressive Disorders in Old Age: Clinical Features and Course</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3509-1622</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафарова</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Safarova</surname><given-names>T. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сафарова Татьяна Петровна - кандидат медицинских наук, ведущий научный сотрудник.</p></bio><bio xml:lang="en"><p>Tatyana P. Safarova - PhD, MD, Cand. of Sci. (Med.), Leading Researcher.</p></bio><email xlink:type="simple">saftatiana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научный центр психического здоровья</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBSI Mental Health Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>01</month><year>2020</year></pub-date><volume>17</volume><issue>3</issue><fpage>87</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сафарова Т.П., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Сафарова Т.П.</copyright-holder><copyright-holder xml:lang="en">Safarova T.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journalpsychiatry.com/jour/article/view/419">https://www.journalpsychiatry.com/jour/article/view/419</self-uri><abstract><sec><title>Цель</title><p>Цель: представить обзор современных отечественных и зарубежных исследований, освещающих проблему депрессий позднего возраста: их распространенность, особенности клиники, течения и исходов.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: с помощью ключевых слов «депрессивные состояния», «поздний возраст» проводился поиск научных статей в базах данных MEDLINE, PUBMED, а также среди других библиографических источников.</p></sec><sec><title>Результаты и выводы</title><p>Результаты и выводы: распространенность депрессивных расстройств в позднем возрасте неуклонно растет в связи с общим постарением популяции. Сохраняются расхождения в представлениях об особенностях психопатологических проявлений, основных тенденциях течения и исходов депрессивных расстройств в позднем возрасте. В последние годы актуализировалось изучение когнитивных дисфункций в структуре депрессивных эпизодов и неполных ремиссий в позднем возрасте в связи с риском исхода заболевания в когнитивное снижение и деменцию. До сих пор не полностью разработана проблема терапии поздних депрессий, связанная с повышенным риском развития нежелательных явлений, медленным развитием терапевтического ответа, высокой частотой рецидивирования и «неполных» выходов из депрессии.</p></sec><sec><title>Заключение</title><p>Заключение: клинические особенности и особенности патогенеза поздних депрессий определяют необходимость дальнейшей научной разработки персонифицированных подходов к терапии и профилактике рецидивов депрессивных расстройств у современного контингента больных позднего возраста.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to provide an overview of domestic and foreign contemporary studies concerning the problem of old age depressions: their prevalence, clinical features, course and outcomes.</p></sec><sec><title>Material and methods</title><p>Material and methods: the keywords «depressive states», «late age» were used to search for scientific articles in the MEDLINE, PUBMED databases, as well as among other bibliographic sources.</p></sec><sec><title>Results and conclusions</title><p>Results and conclusions: the prevalence of depressive disorders at a later age is steadily increasing due to the general aging of the population. Discrepancies in ideas about the characteristics of psychopathological manifestations, main trends in the course and outcomes of depressive disorders at a later age persist. In recent years, the study of cognitive dysfunctions in the structure of depressive episodes and incomplete remissions in late age has been actualized due to the risk of the outcome of the disease in cognitive decline and dementia. The problem of the treatment of late depressions is still not fully developed, which is associated with an increased risk of developing adverse events, a slow development of a therapeutic response, a high recurrence rate and «incomplete» exits from depression.</p></sec><sec><title>Conclusion</title><p>Conclusion: the clinical and pathogenesis features of late depressions determine the need for further scientific development of personalized approaches to the treatment and prevention of relapse of depressive disorders in the current contingent of late age patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>депрессивное расстройство</kwd><kwd>поздний возраст</kwd><kwd>психопатология</kwd><kwd>течение</kwd><kwd>обзор литературы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>depressive disorder</kwd><kwd>old age</kwd><kwd>psychopathology</kwd><kwd>course</kwd><kwd>review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Angst J, Marneros A. 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