psychiatryПСИХИАТРИЯPsychiatry (Moscow) (Psikhiatriya)1683-83192618-6667FSBSI “The Mental Health Research Centre”; LLC «Publisher «MIA»10.30629/2618-6667-2015-67-52-57psychiatry-46Research ArticleВОПРОСЫ КЛИНИЧЕСКОЙ И БИОЛОГИЧЕСКОЙ ПСИХИАТРИИНарушение кластеризации олигодендроцитов в нижней теменной коре при шизофрении: связь с возрастом к началу заболеванияAbnormalities of oligodendrocyte clusters in the inferior parietal cortex in schizophrenia: effect of age at onsetКоломеецНаталья СтепановнаKolomeetsNatalyankolomee@mail.ruУрановаНаталия АлександровнаUranovaNatalyauranovan@mail.ruФГБНУ «Научный центр психического здоровья»РоссияFSBSI «Mental Health Research Center»Russian Federation201528092015035257Copyright © Коломеец Н.С., Уранова Н.А., 20152015Коломеец Н.С., Уранова Н.А.Kolomeets N., Uranova N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journalpsychiatry.com/jour/article/view/46

Цель исследования. Нижняя теменная и префронтальная кора является важной частью гетеромодальной ассоциативной коры, нарушения структуры и функций которой характерны для шизофрении и наиболее выражены у пациентов с ранним началом заболевания, то есть в период интенсивной миелинизации мозга. Ранее в префрональной коре выявлен дефицит олигодендроцитов при шизофрении.Материал и методы исследования. Проведено морфометрическое исследование численной плотности олигодендроцитов и кластеров олигодендроцитов в нижней теменной коре (слой 3 поля 40 по Бродману) в норме и при шизофрении. Исследование выполнено на коллекции срезов аутопсийного мозга Медицинского исследовательского института Стенли (США) c помощью стереологического метода оптического дисектора. Полученные результаты. Показано отсутствие групповых различий в численной плотности олигодендроцитов и снижение на 30% численной плотности кластеров олигодендроцитов при шизофрении по сравнению с контролем ( p < 0,01). Выявленные изменения статистически значимы только для подгруппы случаев шизофрении с ранним началом заболевания (9-18 лет) по сравнению с контролем (- 40%, p < 0,01).Выводы. Выявленный дефицит кластеров олигодендроцитов в мозге больных шизофренией может иметь отношение к нарушению процессов пролиферации и созревания предшественников олигодендроцитов при шизофрении.

Background and Objectives. The inferior parietal and the prefrontal cortex are an essential part of the heteromodal associative cortex involved in the pathophysiology of schizophrenia. Neuroimaging studies demonstrated that abnormalities in the parietal cortex in schizophrenia are associated with early onset of disease that coincides with a key time point in myelination. The deficits of oligodendrocytes have been reported in the prefrontal cortex in schizophrenia.Methods. The morphometric study of the numerical density of oligodendrocytes and oligodendrocyte clusters was performed in the inferior parietal cortex (layer 3 of Brodmann’s area 40) in the normal controls and in the schizophrenia subjects. The autopsy section collection from the Stanley Medical Research Institute (USA) and optical disector method were used for the study.Results. No significant group difference was found in the numerical density of oligodendrocytes. However, the numerical density of oligodendrocyte clusters was 30% lower in the schizophrenia group compared to the control group ( p < 0,01). A significant deficit in the numerical density of oligodendrocyte clusters (- 40%, p < 0,01) was revealed only in the subgroup with early onset of disease (9-18 y.о.) as compared to the controls.Conclusions. The data suggests that the deficit of oligodendrocyte clusters might be associated with altered proliferation and/ or maturation of oligodendrocyte progenitors in schizophrenia.

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The authors declare that there are no conflicts of interest present.