psychiatryПСИХИАТРИЯPsychiatry (Moscow) (Psikhiatriya)1683-83192618-6667FSBSI “The Mental Health Research Centre”; LLC «Publisher «MIA»10.30629/2618-6667-2021-19-2-55-62psychiatry-646Research ArticleПСИХОПАТОЛОГИЯ, КЛИНИЧЕСКАЯ И БИОЛОГИЧЕСКАЯ ПСИХИАТРИЯPSYCHOPATHOLOGY, CLINICAL AND BIOLOGICAL PSYCHIATRYВзаимоотношения нейробиологических и иммунных показателей у больных эпилепсией: значение алекситимииThe Relationships of Neurobiological and Immune Variables in Patients with Epilepsy: The Role of Alexithymiahttps://orcid.org/0000-0001-9546-5852КалининВ. В.KalininV. V.

Калинин Владимир Вениаминович, доктор медицинских наук, профессор, руководитель отдела экзогенно-органических расстройств и эпилепсии

Москва

Vladimir V. Kalinin, MD, PhD, Dr. of Sci. (Med.), Head of the Department

Moscow

doct.kalinin@mail.ruhttps://orcid.org/0000-0001-6570-6977ЗемлянаяА. А.ZemlyanayaA. A.

Земляная Анна Александровна, кандидат медицинских наук, старший научный сотрудник, отдел экзогенно-органических расстройств и эпилепсии

Москва

Anna A. Zemlyanaya, MD, PhD, Cand. of Sci. (Med.)

Moscow

a_zemlyanaya@mail.ruhttps://orcid.org/0000-0001-8091-802XСубботинК. Ю.SubbotinK. Y.

Субботин Кирилл Юрьевич, психиатр, отдел нелекарственных методов лечения

Москва

Kirill Y. Subbotin, Psychiatrist

Moscow

onejrokatatonik1981@gmail.comhttps://orcid.org/0000-0001-9776-7758СоколоваЛ. В.SokolovaL. V.

Соколова Людмила Васильевна, кандидат медицинских наук, психиатр, отдел экзогенно-органических расстройств и эпилепсии

Москва

Liudmila V. Sokolova, MD, PhD, Cand. of Sci. (Med.), Psychiatrist

Moscow

krilo_221160@mail.ruhttps://orcid.org/0000-0003-2149-8971ФедоренкоЕ. А.FedorenkoE. A.

Федоренко Екатерина Андреевна, младший научный сотрудник, отдел экзогенно-органических расстройств и эпилепсии

Москва

Ekaterina A. Fedorenko, Researcher

Moscow

fedorenko_psy@mail.ruМосковский НИИ психиатрии — филиал Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава РоссииРоссияMoscow Research Institute of Psychiatry — the Branch of V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology under the Ministry of Health of the Russian FederationRussian Federation20212506202119255–62Copyright © Калинин В.В., Земляная А.А., Субботин К.Ю., Соколова Л.В., Федоренко Е.А., 20212021Калинин В.В., Земляная А.А., Субботин К.Ю., Соколова Л.В., Федоренко Е.А.Kalinin V.V., Zemlyanaya A.A., Subbotin K.Y., Sokolova L.V., Fedorenko E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journalpsychiatry.com/jour/article/view/646Цель исследования

Цель исследования: изучение взаимоотношений между нейробиологическими, иммунными параметрами и алекситимией у больных эпилепсией.

Пациенты и методы

Пациенты и методы: обследованы 58 больных эпилепсией (26 мужчин, 32 женщины). Височная эпилепсия диагностирована у 25, лобная — у 16 и лобно-височная — у 17 больных. Анализировались частота и тип приступов, длительность ремиссии, тяжесть приступов, уровень алекситимии и показатели клеточного иммунитета. Для анализа связей использовался дисперсионный анализ MANOVA.

Результаты

Результаты: выявлено влияние алекситимии и показателей клеточного иммунитета CD4+ , CD4+ /CD8+ и CD8+ на частоту комплексных фокальных припадков (КФП). При высоких значениях CD4+ , CD4+ / CD8+ и низких значениях CD8+ частота КФП возрастает, что имеет неблагоприятное прогностическое значение. Сочетание алекситимии и правого височного фокуса также приводило к росту частоты и тяжести КФП. Установлены статистически значимые корреляции между величиной алекситимии и напряженностью иммунитета (CD4+ /CD8+ ).

Выводы

Выводы: полученные результаты поддерживают гипотезу о так называемых врожденных иммунных механизмах алекситимии. Определение уровня алекситимии может быть использовано для прогнозирования течения эпилепсии.

Objective

Objective: to study the relationship between neurobiological, immune parameters and alexithymia in patients with epilepsy.

Material and methods

Material and methods: 58 patients with epilepsy (26 men, 32 women) were studied. Temporal epilepsy was diagnosed in 25, frontal — in 16, and frontal-temporal — in 17 patients. The frequency and type of seizures, duration of remission, severity of seizures, level of alexithymia, and parameters of immunity analyzed. To assess the relationships, the analysis of variance MANOVA is used.

Results

Results: the influence of alexithymia and immunological factors CD4+ , CD4+ /CD8+ and CD8+ on the frequency of complex focal seizures (CFS) was revealed. With high CD4+ , CD4+ /CD8+ values and low CD8+ values, the CFS frequency increases, which has an unfavorable prognostic value. The combination of alexithymia and right temporal focus also led to an increase in the frequency and severity of CFS. Statistically signifi cant correlations were found between the alexithymia and the intensity of immunity (CD4+ / CD8+ ).

Conclusions

Conclusions: the results obtained support the hypothesis of the so-called innate immune mechanisms of alexithymia. Determination of the level of alexithymia can be used to predict the course of epilepsy.

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The authors declare that there are no conflicts of interest present.