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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">psychiatry</journal-id><journal-title-group><journal-title xml:lang="ru">ПСИХИАТРИЯ</journal-title><trans-title-group xml:lang="en"><trans-title>Psychiatry (Moscow) (Psikhiatriya)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-8319</issn><issn pub-type="epub">2618-6667</issn><publisher><publisher-name>FSBSI “The Mental Health Research Centre”;   LLC «Publisher «MIA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/2618-6667-2021-19-4-26-33</article-id><article-id custom-type="elpub" pub-id-type="custom">psychiatry-721</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПСИХОПАТОЛОГИЯ, КЛИНИЧЕСКАЯ И БИОЛОГИЧЕСКАЯ ПСИХИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PSYCHOPATHOLOGY, CLINICAL AND BIOLOGICAL PSYCHIATRY</subject></subj-group></article-categories><title-group><article-title>Клинико-терапевтические факторы, влияющие на социальную адаптацию больных шизофренией</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and Therapeutic Factors Affecting the Social Adaptation of Patients with Schizophrenia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4096-6208</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталия Николаевна Петрова, доктор медицинских наук, профессор, заведующая кафедрой психиатрии и наркологии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Nataliia N. Petrova, Dr. of Sci. (Med.), Professor, Head of the Department of Psychiatry and Addiction</p><p>Saint Petersburg</p></bio><email xlink:type="simple">petrova_nn@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0396-1467</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыренова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsyrenova</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кристина Александровна Цыренова, аспирант, кафедра психиатрии и наркологии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Kristina A. Tsyrenova, Postgraduate Student, Department of Psychiatry and Addiction</p><p>Saint Petersburg</p></bio><email xlink:type="simple">kristina.ryuzina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2021</year></pub-date><volume>19</volume><issue>4</issue><fpage>26</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петрова Н.Н., Цыренова К.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Петрова Н.Н., Цыренова К.А.</copyright-holder><copyright-holder xml:lang="en">Petrova N.N., Tsyrenova K.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journalpsychiatry.com/jour/article/view/721">https://www.journalpsychiatry.com/jour/article/view/721</self-uri><abstract><p>Обоснование: в настоящее время остается открытым вопрос о факторах, влияющих на социальное функционирование больных шизофренией, в том числе о роли негативной симптоматики, нейрокогнитивного дефицита и психофармакотерапии. Цель исследования: изучение влияния этих факторов на социальное функционирование пациентов с шизофренией. Пациенты и методы: обследовано 64 больных шизофренией (средний возраст 35,9 ± 10,9 года) на этапе становления ремиссии. Давность заболевания составила 9,71 ± 6,0 лет. Большинство больных переносили параноидные и галлюцинаторно-параноидные приступы (43 и 23% соответственно). В исследовании применялись катамнестический, клинико-психопатологический и психометрический методы: PANSS, SANS, ВАСS, шкалы Калгари и шкалы UKU. Введен интегративный показатель для оценки социальной адаптации пациентов. Результаты: установлено, что показатель социальной адаптации снижается по мере увеличения длительности болезни. На социальную адаптацию влияют побочные эффекты антипсихотической терапии. Применение антипсихотиков второго поколения способствует повышению уровня социального функционирования пациентов. Более низкий уровень социального функционирования с асоциальностью и социальной отгороженностью характерен для пациентов с выраженными апатоабулическими нарушениями, уплощенностью аффекта, ангедонией. Пациенты с удовлетворительным уровнем социальной адаптации отличаются от пациентов с низким уровнем социальной адаптации лучшими показателями слухоречевой памяти, моторных навыков, скорости обработки информации, способностью к планированию и поведению, направленному на решение проблем. Заключение: интегративный показатель социальной адаптации пациентов с шизофренией ассоциирован с рядом когнитивных и негативных симптомов, особенностями антипсихотической терапии и длительностью заболевания.</p></abstract><trans-abstract xml:lang="en"><p>Background: сurrently, the question remains open about the factors that affect the social functioning of patients with schizophrenia, including the role of negative symptoms and neurocognitive deficits. The aim: to study factors that affect the social functioning of patients with schizophrenia. Patients and methods: 64 in-patient with schizophrenia (mean age 35.9 ± 10.9 years) were examined at the stage of remission. The disease duration was 9.71 ± 6.0 years. The majority of patients suffered from paranoid and hallucinatory-paranoid attacs (43 and 23%, respectively). The study used follow-up, clinical and psychopathological methods as well as psychometric scales: PANSS, SANS, ВАСS, Calgary scales and UKU scales. An integrative indicator was introduced to assess the social adaptation of patients. Results: it is shown that as the duration of the disease increases, the indicator of social adaptation decreases. The presence of side effects of antipsychotic therapy is associated with restrictions on the social functioning of patients, but the use of second-generation antipsychotics contributes to an increase in the level of social functioning of patients. Patients with more pronounced apathetic-abulic disorders, flattened affect, anhedonia-asociality and social isolation are characterized by a lower level of social functioning. Adapted patients differ from maladapted patients by better indicators of auditory-speech memory, motor skills, information processing speed, ability to plan and problem solving behavior. Conclusion: the integrative indicator of social adaptation of patients with schizophrenia is associated with a number of cognitive and negative symptoms, features of antipsychotic therapy and the duration of the disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>шизофрения</kwd><kwd>социальное функционирование</kwd><kwd>когнитивное функционирование</kwd><kwd>негативные симптомы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>social functioning</kwd><kwd>schizophrenia</kwd><kwd>cognitive functioning</kwd><kwd>negative symptoms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dziwota E, Stepulak MZ, Włoszczak-Szubzda A, Olajossy M. Social functioning and the quality of life of patients diagnosed with schizophrenia. Ann Agric Environ Med. 2018;25(1):50–55. doi: 10.5604/12321966.1233566 Epub 2017 Jan 11. 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(In Russ.). doi: 10.31363/2313-7053-2019-4-2-87-93</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
