psychiatryПСИХИАТРИЯPsychiatry (Moscow) (Psikhiatriya)1683-83192618-6667FSBSI “The Mental Health Research Centre”; LLC «Publisher «MIA»10.30629/2618-6667-2022-20-4-115-127psychiatry-881Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSКлинико-генетические аспекты депрессий, коморбидных ишемической болезни сердцаClinical and Genetic Aspects of Depression Comorbid Coronary Heart Diseasehttps://orcid.org/0000-0002-6936-6559ДолжиковА. В.DolzhikovA. V.

Должиков Александр Вячеславович.

Москва

Aleksander V. Dolzhikov.

Moscow

Dolgikovav@yandex.ruhttps://orcid.org/0000-0002-5046-6699ТрошинаД. В.TroshinaD. V.

Трошина Дарья Викторовна - кандидат медицинских наук, Институт клинической медицины им. Н.В. Склифосовского.

Москва

Daria V. Troshina - Candidate of Medical Sciences, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University).

Moscow

dtroshina@mail.ruhttps://orcid.org/0000-0002-9960-7114ГолимбетВ. Е.GolimbetV. E.

Голимбет Вера Евгеньевна - доктор биологических наук, профессор, заведующая лабораторией.

Москва

Vera E. Golimbet - Dr. of Sci. (Biol.), Professor, Head of the Laboratory of Clinical Genetics, Mental Health Research Centre.

Moscow

golimbet@mail.ruhttps://orcid.org/0000-0003-1667-5355ВолельБ. A.VolelB. A.

Волель Беатриса Альбертовна - доктор медицинских наук, профессор, директор, Институт клинической медицины им. Н.В. Склифосовского, ПМГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет); НЦПЗ.

Москва

Beatrice A. Volel - Dr. of Sci. (Med.), Professor, Head of the N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University), Mental Health Research Centre.

Moscow

volel_b_a@staff.sechenov.ruНаучный центр психического здоровьяРоссияMental Health Research CentreRussian FederationПервый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University)Russian FederationНаучный центр психического здоровья; Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияMental Health Research Centre; I.M. Sechenov First Moscow State Medical University Ministry of Health of Russian Federation (Sechenov University)Russian Federation202211012023204115127Copyright © Должиков А.В., Трошина Д.В., Голимбет В.Е., Волель Б.A., 20232023Должиков А.В., Трошина Д.В., Голимбет В.Е., Волель Б.A.Dolzhikov A.V., Troshina D.V., Golimbet V.E., Volel B.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journalpsychiatry.com/jour/article/view/881

Цель: провести анализ доступных научных публикаций по проблеме клинико-генетических аспектов депрессивных расстройств у пациентов с ишемической болезнью сердца (ИБС). Материал и методы: по ключевым словам «coronary heart disease», «depression», «genetics», «genetic markers», «polymorphism», «personality», «ишемическая болезнь сердца», «психические расстройства», «депрессия», «генетика», «генетические маркеры», «личность» проведен поиск статей на английском и русском языках в базах данных MEDLINE/PubMed, Scopus, Web of science, eLibrary за период с 1990 по 2022 г. Заключение: депрессивные расстройства при ИБС представляют собой значимую клиническую проблему за счет высокой распространенности, а также влияния на особенности течения и прогноз ИБС, приверженность кардиотропной терапии. Гетерогенность клинической структуры депрессивных расстройств при ИБС (нозогенная, эндогеноморфная, эндогенная, соматогенная депрессии) обусловливает трудности дифференциальной диагностики и проведения комплекса терапевтических мероприятий. Вклад в формирование депрессивных расстройств при ИБС вносит целый ряд факторов: биологических, клинических, личностных. В свою очередь, генетические маркеры депрессий при ИБС, обладающие прогностической ценностью, требуют уточнения.

Objective: to analyze available scientific publications on the problem of clinical and genetic aspects of depressive disorders in patients with coronary heart disease (CHD). Material and methods: by keywords “coronary heart disease”, “mental disorders”, “depression”, “genetics”, “genetic markers”, “polymorphism”, “personality” articles in English and Russian were searched in the MEDLINE/PubMed, Scopus, Web of science, eLibrary databases in the period from 2020 to 2021. Conclusion: depression comorbid CHD is considered as a clinical problem due to its high prevalence, as well as its influence on the features of the course and prognosis of CHD, as well as on the compliance of patients. Heterogeneity of the clinical structure of depressive disorders in CHD (nosogenic, endogenomorphic, endogenous, somatogenic depression) causes difficulties in differential diagnosis and complex therapeutic measures. There are several factors contributing to the onset of depression in CHD patients: biological, clinical, personal characteristics. Genetic markers of depression in CHD, which have prognostic value, require further clarification.

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The authors declare that there are no conflicts of interest present.