Роль синаптического прунинга в этиологии шизофрении


Аннотация

Обзор посвящен анализу статьи А. Sekar и соавт. (2016), в которой впервые в истории молекулярно-генетических исследований шизофрении убедительно показана связь между обнаруженной ранее генетической изменчивостью, ассоциированной с этим заболеванием, и биологическим процессом, имеющим непосредственное отношение к причинам развития шизофрении.

Об авторах

Николай Витальевич Кондратьев
ФГБНУ «Научный центр психического здоровья»
Россия


Вера Евгеньевна Голимбет
ФГБНУ «Научный центр психического здоровья»
Россия


Список литературы

1. Sekar A., Bialas A.R., De Rivera H., Davis A., Hammond T.R., Kamitaki N. et al. Schizophrenia risk from complex vari- ation of complement component 4. Nature. 2016;Feb 11;530(7589):177-183. http://dx.doi.org/10.1038/na- ture16549

2. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-as- sociated genetic loci. Nature. 2014;Jul 24;511(7510):421- 427. http://dx.doi.org/10.1038/nature13595

3. Nguyen H.T.T., Lapaquette P., Bringer M.-A., Darfeuille-Mi- chaud A. Autophagy and Crohn’s disease. J. Innate Immun. 2013;Jan 15;5(5):434-443. http://dx.doi. org/10.1159/000345129

4. Kurk J., Besenyei T., Laki J., Glant T.T., Mikecz K., Szekan- ecz Z. Genetics of rheumatoid arthritis - a comprehensive review. Clin. Rev. Allergy Immunol. 2013;Oct;45(2):170-179. http://dx.doi.org/10.1007/s12016-012-8346-7

5. Visscher P.M., Brown M.A., McCarthy M.I., Yang J. Five years of GWAS discovery. Am. J. Hum. Genet. 2012;Jan 13;90(1):7- 24. http://dx.doi.org/10.1016/j.ajhg.2011.11.029

6. Shi J., Levinson D.F., Duan J., Sanders A.R., Zheng Y., Pe’er I. et al. Common variants on chromosome 6p22.1 are associat- ed with schizophrenia. Nature. 2009;Aug 6;460(7256):753- 757. http://dx.doi.org/10.1038/nature08192

7. Stefansson H., Ophoff R.A., Steinberg S., Andreassen O.A., 66 Cichon S., Rujescu D. et al. Common variants conferring risk of schizophrenia. Nature. 2009;Aug 6;460(7256):744-747. http://dx.doi.org/10.1038/nature08186

8. International Schizophrenia Consortium. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O’Donovan M.C. et al. Com- mon polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;Aug 6;460(7256):748- 752. http://dx.doi.org/10.1038/nature08185

9. Howson J.M.M., Walker N.M., Clayton D., Todd J.A. Type 1 Diabetes Genetics Consortium. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab. 2009;Feb;11 Suppl 1:31-45. http:// dx.doi.org/10.1111/j.1463-1326.2008.01001

10. Raychaudhuri S., Sandor C., Stahl E.A., Freudenberg J., Lee H.-S., Jia X. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropos- itive rheumatoid arthritis. Nat. Genet. 2012;Mar;44(3):291- 296. http://dx.doi.org/10.1038/ng.1076

11. International Multiple Sclerosis Genetics Consortium, Well- come Trust Case Control Consortium 2. Sawcer S., Hellen- thal G., Pirinen M., Spencer C.C.A. et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;Aug 11;476(7359):214-219. http://dx.doi.org/10.1038/nature10251

12. Muller N., Schwarz M. Schizophrenia as an inflamma- tion-mediated dysbalance of glutamatergic neurotransmis- sion. Neurotox Res. 2006;Oct;10(2):131-48. http://dx.doi. org/10.1007/bf03033242

13. Potvin S., Stip E., Sepehry A.A., Gendron A., Bah R., Kouas- si E. Inflammatory cytokine alterations in schizophre- nia: a systematic quantitative review. Biol. Psychiatry. 2008;Apr 15;63(8):801-808. http://dx.doi.org/10.1016/j. biopsych.2007.09.024

14. Upthegrove R., Manzanares-Teson N., Barnes N.M. Cyto- kine function in medication-naive first episode psycho- sis: a systematic review and meta-analysis. Schizophr. Res. 2014;May;155(1-3):101-108. http://dx.doi.org/10.1016/j. schres.2014.03.005

15. Canetta S., Sourander A., Surcel H.-M., Hinkka-Yli-Salomä- ki S., Leiviskä J., Kellendonk C. et al. Elevated maternal C-re- active protein and increased risk of schizophrenia in a na- tional birth cohort. Am. J. Psychiatry. 2014;Sep;171(9):960- 968. http://dx.doi.org/10.1176/appi.ajp.2014.13121579

16. Khandaker G.M., Zimbron J., Lewis G., Jones P.B. Prenatal maternal infection, neurodevelopment and adult schizo- phrenia: a systematic review of population-based stud- ies. Psychol. Med. 2013;Feb;43(2):239-257. http://dx.doi. org/10.1017/S0033291712000736

17. Torrey E.F., Bartko J.J., Yolken R.H. Toxoplasma gondii and other risk factors for schizophrenia: an update. Schizophr. Bull. 2012;May;38(3):642-647. http://dx.doi.org/10.1093/ schbul/sbs043

18. Arias I., Sorlozano A., Villegas E., De Dios Luna J., McKen- ney K., Cervilla J. et al. Infectious agents associat- ed with schizophrenia: a meta-analysis. Schizophr Res. 2012;Apr;136(1-3):128-136. http://dx.doi.org/10.1016/j. schres.2011.10.026

19. Ferentinos P., Dikeos D. Genetic correlates of medical comor- bidity associated with schizophrenia and treatment with antipsychotics. Curr. Opin. Psychiatry. 2012;Sep;25(5):381- 390. http://dx.doi.org/10.1097/YCO.0b013e3283568537

20. Зозуля С.А., Сирияченко Т.М., Каледа В.Г., Дупин А.М., Омельченко М.А., Отман И.Н., Клюшник Т.П. Особенно- сти состояния иммунной системы при эндогенных пси- хических заболеваниях с выраженными аффективными расстройствами. Журнал неврологии и психиатрии им. C.C. Корсакова. 2011;111(12):63-67. Доступно по: http:// www.ncbi.nlm.nih.gov/pubmed/22433812 Ссылка активна на 30.06.2016

21. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet. 2011;Oct;43(10):977-983. http://dx.doi. org/10.1038/ng.943

22. Boin F., Zanardini R., Pioli R., Altamura C.A., Maes M., Gennarelli M. Association between-G308A tumor necro- sis factor alpha gene polymorphism and schizophrenia. Mol. Psychiatry. 2001;Jan;6(1):79-82. http://dx.doi. org/10.1038/sj.mp.4000815

23. Wei J., Hemmings G.P. The NOTCH4 locus is associat- ed with susceptibility to schizophrenia. Nat. Genet. 2000;Aug;25(4):376-367. http://dx.doi.org/10.1038/78044

24. Farrell M.S., Werge T., Sklar P., Owen M.J., Ophoff R.A., O’Donovan M.C. et al. Evaluating historical candidate genes for schizophrenia. Mol. Psychiatry. 2015;May;20(5):555- 562. http://dx.doi.org/10.1038/mp.2015.16

25. Schwab S.G., Albus M., Hallmayer J., Hönig S., Borrmann M., Lichtermann D. et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet. 1995;Nov;11(3):325- 327. http://dx.doi.org/10.1038/ng1195-325

26. Antonarakis S.E., Blouin J.L., Pulver A.E., Wolyniec P., Lasse- ter V.K., Nestadt G. et al. Schizophrenia susceptibility and chromosome 6p24-22. Nat. Genet. 1995;Nov;11(3):235-236. http://dx.doi.org/10.1038/ng1195-235

27. Wang S., Sun C.E., Walczak C.A., Ziegle J.S., Kipps B.R., Goldin L.R. et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat. Genet. 1995;May;10(1):41-46. http://dx.doi.org/10.1038/ng0595-41

28. Additional support for schizophrenia linkage on chro- mosomes 6 and 8: a multicenter study. Schizophre- nia Linkage Collaborative Group for Chromosomes 3, 6 and 8. Am. J. Med. Genet. 1996;Nov 22;67(6):580-594. 3.0.CO;2-P">http://dx.doi.or g/10.1002/(SICI)1096- 8628(19961122)67:6<580::AID-AJMG11>3.0.CO;2-P

29. Mayilyan K.R., Weinberger D.R., Sim R.B. The comple- ment system in schizophrenia. Drug News Perspect. 2008;May;21(4):200-210. http://dx.doi.org/10.1358/ dnp.2008.21.4.1213349

30. Escudero-Esparza A., Kalchishkova N., Kurbasic E., Jiang W.G., Blom A.M. The novel complement inhibitor human CUB and Su- shi multiple domains 1 (CSMD1) protein promotes factor I-me- diated degradation of C4b and C3b and inhibits the membrane attack complex assembly. FASEB J. 2013;Dec;27(12):5083- 5093. http://dx.doi.org/10.1096/fj.13-230706

31. Ting C.N., Rosenberg M.P., Snow C.M., Samuelson L.C., Meis- ler M.H. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev. 1992;Aug;6(8):1457-1465. doi: 10.1101/ gad.6.8.1457 Genes & Dev. 1992. 6: 1457-1465

32. Sverdlov E.D. Retroviruses and primate evolution. Bioes- 68 says. 2000;Feb;22(2):161-171. 3.0. CO;2-ht tp://dx.d oi.or g/10.10 02/(SICI)1521- 1878(200002)22:2<161::AID-BIES7>3.0.CO;2-X

33. Suntsova M., Gogvadze E.V., Salozhin S., Gaifullin N., Ero- shkin F., Dmitriev S.E. et al. Human-specific endogenous retroviral insert serves as an enhancer for the schizophre- nia-linked gene PRODH. Proc. Natl. Acad. Sci USA. 2013;Nov 26;110(48):19472-19477. http://dx.doi.org/10.1073/ pnas.1318172110

34. Stevens B., Allen N.J., Vazquez L.E., Howell G.R., Chris- topherson K.S., Nouri N. et al. The classical complement cascade mediates CNS synapse elimination. Cell. 2007;Dec 14;131(6):1164-1178. ht tp://dx.doi.or g/10.1016/j. cell.2007.10.036

35. Garey L.J., Ong W.Y., Patel T.S., Kanani M., Davis A., Morti- mer A.M. et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J. Neurol. Neu- rosurg. Psychiatry. 1998;Oct;65(4):446-453. http://www. ncbi.nlm.nih.gov/pubmed/9771764

36. Schafer D.P., Lehrman E.K., Kautzman A.G., Koyama R., Mardinly A.R., Yamasaki R. et al. Microglia sculpt postna- tal neural circuits in an activity and complement-depen- dent manner. Neuron. 2012;May 24;74(4):691-705. http:// dx.doi.org/10.1016/j.neuron.2012.03.026

37. Lui H., Zhang J., Makinson S.R., Cahill M.K., Kelley K.W., Huang H.-Y. et al. Progranulin Deficiency Promotes Cir- cuit-Specific Synaptic Pruning by Microglia via Comple- ment Activation. Cell. 2016;May 5;165(4):921-935. http:// dx.doi.org/10.1016/j.cell.2016.04.001

38. Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J. Psychiatr. Res. 1982;17(4):319-334. http://dx.doi.org/10.1016/0022- 3956(82)90038-3

39. Petanjek Z., Judaš M., Šimic G., Rasin M.R., Uylings H.B.M., Rakic P. et al. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc. Natl. Acad. Sci USA. 2011;Aug 9;108(32):13281-13286. http://dx.doi. org/10.1073/pnas.1105108108

40. Faludi G., Mirnics K. Synaptic changes in the brain of subjects with schizophrenia. Int. J. Dev. Neurosci. 2011;May;29(3):305-309. http://dx.doi.org/10.1016/j.ij- devneu.2011.02.013

41. Andreasen N.C., Nopoulos P., Magnotta V., Pierson R., Zie- bell S., Ho B.-C. Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizo- phrenia. Biol. Psychiatry. 2011;Oct1;70(7):672-679. http:// dx.doi.org/10.1016/j.biopsych.2011.05.017


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Для цитирования: Кондратьев Н.В., Голимбет В.Е. Роль синаптического прунинга в этиологии шизофрении. Психиатрия. 2016;(70):62-69.

For citation: ., . . Psychiatry. 2016;(70):62-69.

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