Алимемазин в амбулаторной терапии непсихотических психических расстройств у подростков

The aim of the study was to analyse the efficacy of alimemazine in the outpatient treatment of non-psychotic disorders in adolescents.Materials and methods. Clinical psychopathological examination of 56 patients aged 15-17 (37 youths and 19 girls) was carried out. They were also examined using the Clinical Global Impression Scale (CGI). 3 groups of patients were singled out, taking into consideration the nosological nature of psychic pathology. The 1st group (28 subjects; 49.9%) included adolescents with schizophrenia spectrum disorders. The 2nd group (20 adolescents; 35.7%) consisted of patients with neurotic impairments. The 3rd group (8 subjects; 14.4%) embraced patients with organic non-psychotic impairments, including personality disorders of organic nature.The results and conclusion. In whole clinical improvement of various degree of intensity was noticed in 46 (82,1%) of adolescents in 4 weeks of treatment. 8 weeks later the patients demonstrated indices of continuing positive dynamics: moderate improvement changed into expressed one in 5 of them (8,9%); minimal improvement gave place to moderate one in 2 more patients (3,6%). 17,9% of subjects showed stable condition (no improvement was observed); however one third of non-responders (3 subjects - 5,4%) demonstrated positive dynamics of their mental status at additional inclusion of antidepressive drugs from the group of selective serotonin re-uptake inhibitors (SSRI) in their treatment. High efficacy, affinity to anxious, phobic, affective, obsessive, and somato- vegetative impairments, possibility of use in complex therapy and practically complete absence of undesirable effects testify to mild and balanced impact of the drug, its congruence with «targets syndromes» typical of the patients of adolescent age.

алимемазин, подростки, психические расстройства, лечение, эффективность, нежелательные явления, alimemazine, adolescents, mental disorders, treatment, efficacy, undesirable effects

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