Effect of Lithium Taurate on Behavioral-Exploratory Activity and Anxiety in Rats in a Chronic Experiment
https://doi.org/10.30629/2618-6667-2026-24-1-78-85
Abstract
Background: lithium salts play a fundamental role in the treatment of depression with various etiopathogenetic causes. Lithium carbonate, — the most commonly used anxiolytic, — has numerous toxic effects, making it important to search for a less toxic anxiolytic. Given the numerous positive effects of the non-proteinogenic amino acid taurine, its lithium salt may be one of the newest and most promising anxiolytics. However, the specific activity of lithium taurate has not been studied during chronic administration. The aim of this study was to investigate the effects of lithium taurate on behavioral activity and anxiety in laboratory rats. Materials and Methods: two hundred non-inbred rats of both sexes were administered an aqueous solution of lithium taurate diluted in 2 ml of water intragastrically via an atraumatic tube once daily for 6 months at doses of 196 mg/kg (minimum), 273 mg/kg (average), and 350 mg/kg (maximum). The placebo group, which received an equivalent volume of water for injection intragastrically, and intact animals of both sexes served as controls. Behavioral activity and anxiety were assessed using the open field test. Results and Conclusions: lithium taurate in all dosages eliminates gender differences in the effects of stress from prolonged intragastric tube insertion.
Supporting agencies: The research was conducted as part of a preclinical study of lithium taurate (R&D Reg. no. 20230679) within the framework of event 23 «To develop and master the technology for the production of pharmaceutical substances and antipsychotic drugs based on organic lithium salt» of subprogram 5 «Chemical products and molecular technologies» of the State Program «High-tech Technologies and Technology» for 2021–2025.
About the Authors
Y. Yu. Kozlova
Vitebsk State Order of Peoples Friendship Medical University
Belarus
Belarus
Yana Yu. Kozlova, Researcher, Research Laboratory
Vitebsk
S. S. Osochuk
Vitebsk State Order of Peoples Friendship Medical University
Belarus
Belarus
Sergey S. Osochuk, Dr. Sci. (Med.), Professor, Head of the research laboratory
Vitebsk
Z. I. Kuvaeva
The Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Zoya I. Kuvaeva, Dr. Sci. (Chem.), Professor, Head of Department, Department of Drug Substances
Minsk
E. G. Karankevich
The Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena G. Karankevich, Cand. Sci. (Chem.)., Head of Laboratory, Laboratory of Synthesis and Research of Properties of Biologically Active Substances
Minsk
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Review
For citations:
Kozlova Y.Yu., Osochuk S.S., Kuvaeva Z.I., Karankevich E.G. Effect of Lithium Taurate on Behavioral-Exploratory Activity and Anxiety in Rats in a Chronic Experiment. Psychiatry (Moscow) (Psikhiatriya). 2026;24(1):78-85. (In Russ.) https://doi.org/10.30629/2618-6667-2026-24-1-78-85
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