Сlinical and сhronobiological aspects of depression treatment
https://doi.org/10.30629/2618-6667-2017-76-45-51
Abstract
Objective: to evaluate chronobiological pattern of depression and its impact on the therapeutic regimen. Material and methods: the study included 100 depressive patients. All participants completed a questionnaire package (MADRS, HDRS-21, CGI, cyclicity index, Questionnaire Scoring Subjective Characteristics of Sleep, PSQI, TOB, SPAQ, MEQ). Results: sleep disturbances were highly prevalent in recurrent group (4,1 ± 1,1 points; MADRS, item 4; time to fall asleep — 53,58 min, PSQI), diurnal variation of symptoms with morning worsening, compared to single episode (p < 0,05). Shortening of the «individual minute», especially in the age group 60–77 years (mean value: 39) reflected the severity depression severity in the sample. The TOB test demonstrated a subjective slowing of time (23,9 ± 4,04 points). Seasonal depression (SAD) was revealed in 13% of cases. Three main chronotypes (morning — 12%, evening — 30%, and mid-range — 58%) were identifed. Eveningness had associated with a positive family history of affective disorders, an early onset (30,43 ± 12,9; p < 0,01), younger age at the time of treatment (42,73 ± 16,04; p < 0,05), large number (4 [2; 6], p > 0,05) and length of episodes (months) (3 [2; 5], p < 0,05), a more severe depression and intensive treatment program (antianxiety agents, hypnotics). Antidepressants were more effective given at morning in ETs, at evening — in MTs. Conclusions: biological rhythms are individual characteristics that should be taken into account when prescribing antidepressants and other agents.
About the Author
Maria Gerasimchuk
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation
postgraduate student, department of psychiatry and addiction
Russian Federation
postgraduate student, department of psychiatry and addiction
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For citations:
Gerasimchuk M. Сlinical and сhronobiological aspects of depression treatment. Psychiatry (Moscow) (Psikhiatriya). 2017;(76):45-51. (In Russ.) https://doi.org/10.30629/2618-6667-2017-76-45-51
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