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Психиатрия

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Патология олигодендроглии и когнитивные расстройства при шизофрении

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Аннотация

Цель обзора: представить новые литературные данные об участии олигодендроцитов и миелина в когнитивной дисфункции при шизофрении. Материал и метод: систематический обзор литературы. Результаты: настоящий обзор посвящен роли олигодендроцитов и миелина в когнитивных функциях мозга, патологии олигодендроцитов и миелина в мозге при шизофрении, связи нарушений олигодендроцитов и миелина с когнитивной дисфункцией у больных шизофренией и влиянию лечения на олигодендроциты и когнитивные нарушения. Важное значение нарушений структуры и функций олигодендроцитов и миелинизации мозга в патогенезе когнитивных расстройств при шизофрении подтверждены результатами нейровизуализационных, генетических, биохимических и морфометрических исследований мозга больных шизофренией. Заключение: стимуляция олигодендроглиогенеза и миелиногенеза в коре больших полушарий может стать новой стратегией в лечении когнитивных расстройств у больных шизофренией.

Об авторе

Наталия Александровна Уранова
ФГБНУ «Научный центр психического здоровья», Москва
Россия

доктор медицинских наук, заведующий лабораторией клинической
нейроморфологии



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Для цитирования:


Уранова Н.А. Патология олигодендроглии и когнитивные расстройства при шизофрении. Психиатрия. 2017;(76):77-88.

For citation:


Uranova N. Pathology of oligodendroglia and cognitive impairment in schizophrenia. Psychiatry. 2017;(76):77-88. (In Russ.)

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