The clinical and biological relationships in HIV-infected schizophrenic patients and schizoaffective disorder

Objective. The aim of study included the definition ofline of immunological characteristic(CD3⁺CD4⁺, CD3⁺CD8⁺ T-limphocytes) and the search of clinical and biological relationships in HIV-infected patients with schizophrenia and schizoaffective disorder.

Patients and methods. 96 HIV-infected patients (58 females and 38 males) with schizophrenia and schizoaffective disorder were included into clinical and immunological study. Methods of statistics: the correlation analysis; comparison of mean values.

The main results: The HIV-infection in patients with schizophrenia and schizoaffective disorder reduce the levels of immunocompetent cells. There are statistically relationships between psych о path о logical symptoms (PANSS) and several immunity variables in HIV-infected patients with schizophrenia and schizoaffective disorder have been obtained. The increase of CD3*CD8* T-lymphocytes in HIV-infected patients corresponded to psychoses with hallucinations and delusions, but not to affective and schizoaffective syndromes. The preserved level of T-lymphocytes has been revealed in patients with schizoaffective disorder and attack-like schizophrenia. Quite the contrary, the reduction of CD3⁺CD4⁺ T-lymphocytes, CD3⁺CD8⁺  T-lymphocytes and CD4^+/CD8⁺ ratio has been registered in patients with paranoid schizophrenia with continual and episodic course. Duration of the HIV-infection is softening the intensity of psychopathological symptomatology.

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