Chronic fatigue syndrome
https://doi.org/10.30629/2618-6667-2018-80-74-81
Abstract
Summary: Chronic fatigue is a persistent state of extreme weakness, exhaustion, loss of strength (physical and/or mental), which occurs spontaneously or as a result of a previous activity and makes it impossible to perform a new activity. Chronic fatigue syndrome – a condition with an unclearly defined status, the main manifestation of which is rapid fatigue, persisting for at least several months, which cannot be explained by another disease or syndrome within a specific disease, current physical exertion. It is often referred to somatoform disorders due to psychopathological symptoms. However, the pathogenesis of this syndrome is largely determined by immunopathological, neurotransmitter, neuroendocrine mechanisms, which are involved in varying degrees in the primary and secondary forms of the syndrome. Treatment continues to be primarily empirical and includes methods of cognitive behavioral therapy, measured physical activity, normalization of sleep, the use of antidepressants, anxiolytics, and neurometabolic agents.
Keywords
About the Authors
V. K. DatievaRussian Federation
neurologist, SBIH State Clinic № 157 MHD
Moscow, Russian Federation
A. Sh. Chimagomedova
Russian Federation
MD,
Moscow, Russian Federation
O. S. Levin
Russian Federation
Dr. of Sci. (Med.), professor
Moscow, Russian Federation
References
1. Alves G., Wentzel-Larsen Т., Larsen J.P. Is fatigue an independent and persistent symptom in patients with Parkinson's disease. Neurology. 2004;63:1908–1911. https://DOI.org/10.1212/01.wnl.0000144277.06917.cc
2. Chaudhuri K.R., Schapira A.H.V. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009;8:464–674. https://DOI.org/10.1016/s1474–4422(09)70068–7
3. Chou K.L., Persad C.C., Patil P.G. Change in fatigue after bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease. Parkinsonism Relat. Disord. 2012;18:510–513. https://DOI.org/10.1016/j.parkreldis.2012.01.018
4. Friedman J.H., Friedman H. Fatigue in Parkinsons disease: a nine-year follow-up. Mov. Disord. 2001;16:1120–1122. https://DOI.org/10.1002/mds.1201
5. Critchley P.H., Malcolm G.P. Fatigue and melatonin in Parkinson's Disease. J. Neurol. Neurosurg. Psychiatry. 1991;54:91–92. https://DOI.org/10.1136/jnnp.54.1.91
6. van Hilten J.J., Weggeman M., van der Velde E.A. Sleep, excessive daytime sleepiness and fatigue in Parkinson's disease. J. Neural. Transm. Park. Dis. Dement. Sect. 1993;5(3):235–244. https://DOI.org/10.1007/bf02257678
7. Levin O.S., Smolentseva I.G., Ivanov A.K. Nonmotor fluctuations in Parkinson's disease. Zhurnal nevrologii i psikhiatrii im. Korsakova. 2010;3:90–96. (In Russ.).
8. Hagell P., Brundin L. Towards an understanding of fatigue in Parkinson disease. J. Neurol. Neurosurg. Psychiatry. 2009;80:489–492. https://DOI.org/10.1136/jnnp.2008.159772
9. Pavese N., Metta V., Bose S.K. et al. Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain. 2010;133:3434–3443. https://DOI.org/10.1093/brain/awq268
10. Goldstein D. Dysautonomia in Parkinson's disease: neurocardiological abnormalities. Lancet Neurol. 2003;2:669–676. https://doi.org/10.1016/s1474–4422(03)00555–6
11. Perez–Lloret S., Rey M. Factors related to orthostatic hypotension in Parkinson's disease. Parkinsonism Relat. Disord. 2012;18:501–505. https://DOI.org/10.1016/s1353–8020(11)70605–8
12. Brown R.G., Dittner A., Findley L. et al. The Parkinson fatigue scale. Parkinsonism Relat. Disord. 2005;11:49–55. https://DOI.org/10.1016/j.parkreldis.2004.07.007
13. Morley J. Undernutrition in older adults. Fam. Pract. 2012;29:89–93. https://DOI.org/10.1093/fampra/cmr054
14. Levin O.S., Smolentseva I.G., Zeredsodnom B. Influence of dopaminergic therapy on cognitive functions in patients with Parkinson's disease. Nevrologicheskii zhurnal. 2004;3:31–37. (In Russ.).
15. Barone P., Scarzella L., Antonini A. et al. Pramipexole versus sertraline in the treatment of depression in Parkinson's disease. J. Neurol. 2005;4:1–7. https://DOI.org/10.1007/s00415–006–0067–5
16. Avedisova A.S. Therapy of asthenia. Farmazevticheskii vestnik. 2003;3(282):15–16. (In Russ.).
17. Voznesenskaya T.G, Fokina N.M., Yakhno N.N. Therapy of asthenia in patients with psychoautonomic syndrome. Zhurnal nevrologii i psikhiatrii im. Korsakova. 2010;110(5):17–26. (In Russ.).
18. Vorobjeva O.V. Versatility of asthenia. RMJ. 2012;5:248–252. (In Russ.).
19. Vorob'eva O.V., Rusaya V.V. Effektivnost' i bezopasnost' preparata noofen v terapii sindroma hronicheskoj ustalosti u bol'nyh s cerebrovaskulyarnoj nedostatochnost'yu. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2017;117:11:31–36. https://doi.org/10.17116/jnevro201711711131-36 (In Russ.).
20. Chutko L.S., Surushkina S.Yu., Nikishena I.S., Yakovenko Е.A., Rozhkova A.V., Anisimova T.I. Kliniko-nejrofiziologicheskoe issledovanie effektivnosti preparata adaptol pri lechenii sindroma emocional'nogo vygoraniya. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2010;110:10:30–33. (In Russ.).
21. Chutko L.S. Svetit' i ne sgorat'. Profilaktika sindroma emocional'nogo vygoraniya: Uchebno-metodicheskoe posobie. M.: OOO «Medicinskoe informacionnoe agentstvo», 2019:24. (In Russ.).
Review
For citations:
Datieva V.K., Chimagomedova A.Sh., Levin O.S. Chronic fatigue syndrome. Psychiatry (Moscow) (Psikhiatriya). 2018;(80):74-81. (In Russ.) https://doi.org/10.30629/2618-6667-2018-80-74-81