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Роль системы комплемента в патогенезе вирусной инфекции SARS-CoV-2 при психических заболеваниях

https://doi.org/10.30629/2618-6667-2021-19-4-76-89

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Аннотация

Введение: система комплемента может быть критическим фактором, определяющим исход коронавирусной инфекции COVID-19. Для многих психических заболеваний характерно системное стерильное воспаление, обязательным участником которого является система комплемента. Цель: представить анализ научных данных о роли системы комплемента в патогенезе вирусных заболеваний и особенностей течения COVID-19 у психически больных. Материал и методы: с помощью ключевых слов «система комплемента и коронавирусная инфекция 2019», «ингибирование системы комплемента», «коронавирусная инфекция 2019 и психические заболевания» проводился поиск научных статей в базах данных MEDLINE, PubMed и других источниках. Заключение: пациенты с психическими заболеваниями относятся к группе риска в силу физиологических и ментальных особенностей, а инфицирование вирусом SARS-CoV-2 может провоцировать рецидив основного заболевания. Терапевтическое ингибирование системы комплемента поможет снизить этот риск и уменьшить вероятность тяжелых осложнений при системном воспалении, вызванном этой инфекцией.

Об авторах

Е. Г. Черемных
Научный центр психического здоровья
Россия

Елена Григорьевна Черемных, кандидат технических наук, лаборатория биохимии

Москва



П. А. Иванов
Научный центр психического здоровья
Россия

Павел Александрович Иванов, кандидат биологических наук, лаборатория нейроиммунологии

Москва



М. И. Фактор
Научный центр психического здоровья
Россия

Магнолия Иосифовна Фактор, кандидат биологических наук, лаборатория биохимии

Москва



А. Н. Позднякова
Научный центр психического здоровья
Россия

Анастасия Николаевна Позднякова, младший научный сотрудник, лаборатория нейрофизиологии

Москва



Ю. Е. Шилов
Научный центр психического здоровья
Россия

Юрий Евгеньевич Шилов, кандидат биологических наук, лаборатория биохимии

Москва



О. С. Брусов
Научный центр психического здоровья
Россия

Олег Сергеевич Брусов, кандидат биологических наук, заведующий лабораторией, лаборатория биохимии

Москва



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Рецензия

Для цитирования:


Черемных Е.Г., Иванов П.А., Фактор М.И., Позднякова А.Н., Шилов Ю.Е., Брусов О.С. Роль системы комплемента в патогенезе вирусной инфекции SARS-CoV-2 при психических заболеваниях. ПСИХИАТРИЯ. 2021;19(4):76-89. https://doi.org/10.30629/2618-6667-2021-19-4-76-89

For citation:


Cheremnykh E.G., Ivanov P.A., Factor M.I., Pozdnyacova A.N., Shilov Y.E., Brusov O.S. The Role of the Complement System in the Pathogenesis of SARS-CoV-2 Viral Infection in Mental Illness. Psikhiatriya. 2021;19(4):76-89. (In Russ.) https://doi.org/10.30629/2618-6667-2021-19-4-76-89

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ISSN 1683-8319 (Print)
ISSN 2618-6667 (Online)