Early Desadaptation in Children with Autism Spectrum Disorders: Disability Risk Factors
https://doi.org/10.30629/2618-6667-2022-20-2-60-67
Abstract
Background: according to WHO, mental disorders that occur in childhood account for the largest share of child disability among all diseases. Special attention is paid to the problem of autism spectrum disorders, the growth of which in the world over the past 10 years has amounted to 1300%, and the disability rate has increased by 107.1% in 5 years. The purpose of the study: identication of risk factors for the formation of early disability in children with autism spectrum disorders. Patients and methods: the study made up 518 children diagnosed with autism spectrum disorder, divided into 2 groups: disabled children and non-disabled children. Clinical-psychopathological, clinical-catamnestic, psychometric, and statistical methods were used in the work. Results: the inuence of a signicant number of disabling risk factors in children with ASD was revealed, while the strength of their impact varied in a very wide range. For practical application, 3 main groups of disability risk factors are identied (organizational, reproductive health of parents, factors of pregnancy and childbirth) and the strength of their total inuence on the formation of disability is established statistically. Discussion: the obtained data showed that the power of the total inuence of “organizational” factors on the formation of disability in autism spectrum disorders is 2 times greater than the power of factors “reproductive health of parents” and more than 5 times the power of the impact of pregnancy and childbirth, which corresponded to a high statistical signicance (p < 0.001). Hereditary factors did not have a signicant impact on the formation of disabling mental disorders. Conclusion: the system of prevention, early diagnostics and comprehensive rehabilitation based on interdisciplinary interaction contributes to improve adaptation and quality of life of children with autism spectrum disorders and their families.
About the Authors
Zh. V. Albitskaya
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Zhanna V. Albitskaya, Dr. of Sci. (Med.), Associate Professor, Department of Psychiatry
Niznii Novgorod
V. A. Tsarev
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Vyacheslav A. Tsarev, Studen
Niznii Novgorod
M. K. Kozlov
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Maksim К. Kozlov, Student
Niznii Novgorod
References
1. WHO. The health situation of children and adolescents in Europe [Internet].2018 [cited 02.02.2021]. Available from: http://www.euro.who.int/ru/publications/abstracts/situation-of-child-and-adolescent-health-in-europe-2018
2. Demcheva NK. Indicators of disability of children by mental illness in the Russian Federation in 2002– 2012. Glavvrach = Сhief medical ofcer. 2014;5:3–10. (In Russ.).
3. Makushkin EV. Priority areas of child health protection in neurology and psychiatry (diagnosis, therapy, rehabilitation and prevention). Results of the scientic and practical conference. Journal of New Medical Technologies. eEdition. 2011;18(4):291–293. (In Russ.).
4. Sukhotina NK. Mental health of children and its determining factors. S.S. Korsakov Journal of Neurology and Psychiatry/Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2013;5:16–22. (In Russ.).
5. Demcheva NK. Problemy invalidnosti detei s psikhicheskimi rastroistvami. In: Vserossiiskaia konferentsiia po detskoi psikhiatrii i narkologii “Psikhicheskoe zdorov’e detei strany — budushchee zdorov’e natsii”. 2016;128–130.
6. Makushkin EV, Fesenko YuA, Shigashov DYu. Detskaya psikhiatricheskaya sluzhba strany [Child psychiatric service of the country]. Moscow. Yurayt Publ. 2019. (In Russ.).
7. Makushkin EV, Makarov IV, Pashkovsky VE. Prevalence of autism: genuine and imaginary. S.S. Korsakov Journal of Neurology and Psychiatry/Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2019;119(2):80–86. (in Russ.). doi: 10.17116/jnevro201911902180
8. Aas M, Haukvik UK, Djurovic S, Tesli M, Athanasiu L, Bjella T, Hansson L, Cattaneo A, Agartz I, Andreassen OA, Melle I. Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders. J Psychiatr Res. 2014;59:14–21. doi: 10.1016/j.jpsychires.2014.08.011 Epub 2014 Aug 30. PMID: 25246365
9. Bugie C. Child development and early intervention centers. Rev Neurol. 2013;(34,Suppl.1):143–148. (Spain.)
10. Garralda ME, Raynaud J-Ph. Brain, mind, and developmental psychopathology in childhood. International Association of Child and Adolescent Psychiatry and Allied Professions (IACAPAP). 2012:317 p.
11. Tirosh E, Jaffe M. Global developmental delay and mental retardation — a pediatric perspective. Dev Disabil Res Rev. 2011;17(2):85–92. doi: 10.1002/ddrr.1103 PMID: 23362028.
12. Thurgate C, Warner H. Living with disability: part 1. Paediatr Nurs. 2005;17(10):37–44. doi: 10.7748/ paed2005.12.17.10.37.c983 PMID: 16372709
13. Albitskaya JV. Problems of diagnosis and quality of mental health care delivery as a predictor of the formation of disabling mental disorders in children. Sotsial’naya i klinicheskaya psikhiatriya. 2018:8–24. (In Russ.).
14. Albitskaya JV. Biomedical predictors of the formation of disabling mental disorders in childhood. Meditsinskiy al’manakh. 2018;5:164–169. (In Russ.). doi: 10.21145/2499-9954-2018-5-164-168
15. Partialis EM. Risk factors for cognitive impairment in children (review). Novye issledovaniya. 2013;2:4–22. (In Russ.).
16. Prilipenko YuV. Risk factors and prevention of possible developmental disorders at an early age. Mir nauki, kul’tury i obrazovaniya. 2014;6:252. (In Russ.).
17. Korkmaz B. Theory of mind and neurodevelopmental disorders of childhood. Pediatr Res. 2011;69(5Pt 2):101R–8R. doi: 10.1203/PDR.0b013e318212c177 PMID: 21289541
18. Sanchack KE, Thomas CA. Autism Spectrum Disorder: Primary Care Principles. Am Fam Physician. 2016;94(12):972–979. PMID: 28075089
19. Chisholm K, Lin A, Abu-Akel A, Wood SJ. The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence. Neurosci Biobehav Rev. 2015;55:173–183. doi: 10.1016/j.neubiorev.2015.04.012 Epub 2015 May 5. PMID: 25956249
20. Elsabbagh M. Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience? BMJ. 2020;368:–l6880. doi: 10.1136/bmj. l6880 PMID: 31992555
21. Dolotova NV. Prevention of health disorders in children of the rst year of life who have suffered perinatal damage to the central nervous system, taking into account family risk factors. Palliativnaya meditsina i reabilitatsiya. 2013;(4):25–27. (In Russ.).
22. Bhandari R, Paliwal JK, Kuhad A. Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors. Adv Neurobiol. 2020;24:97–141. doi: 10.1007/978-3030-30402-7_4 PMID: 32006358
23. Myers SM, Johnson CP; American Academy of Pediatrics Council on Children With Disabilities. Management of children with autism spectrum disorders. Pediatrics. 2007;120(5):1162–1182. doi: 10.1542/peds.2007-2362 Epub 2007 Oct 29. PMID: 17967921
24. Takumi T, Tamada K, Hatanaka F, Nakai N, Bolton PF. Behavioral neuroscience of autism. Neurosci Biobehav Rev. 2020;110:60–76. doi: 10.1016/j.neubiorev.2019.04.012 Epub 2019 May 3. PMID: 31059731
25. Arberas C, Ruggieri V. Autismo. Aspectos genéticos y biológicos [Autism. Genetic and biological aspects]. Medicina (B Aires). 2019;79(Suppl. 1):16–21. (Spanish). PMID: 30776274
Review
For citations:
Albitskaya Zh.V., Tsarev V.A., Kozlov M.K. Early Desadaptation in Children with Autism Spectrum Disorders: Disability Risk Factors. Psychiatry (Moscow) (Psikhiatriya). 2022;20(2):60-67. (In Russ.) https://doi.org/10.30629/2618-6667-2022-20-2-60-67
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