Медико-биологические и потенциальные терапевтические аспекты использования препарата лития карбоната
Аннотация
Обоснование: соль карбоната лития используется в психиатрии при состояниях возбуждения, для предотвращения рецидивов маниакальных и депрессивных эпизодов, а также для лечения агрессивного поведения. Фармакологические характеристики карбоната лития изучены не полностью. В последнее время наблюдается повышение интереса к более широкому использованию препарата, например при терапии нейродегенеративных заболеваний и даже при вирусных инфекциях. Цель: представить обзор наиболее ранних современных зарубежных исследований, освещающих медико-биологические и потенциальные терапевтические аспекты использования препарата карбоната лития не по традиционным показаниям. Материал и методы: по ключевым словам «карбонат лития, нейропротекция, токсичность, болезнь Альцгеймера, коронавирусная инфекция» проводился поиск научных публикаций в базах данных MEDLINE, PubMed, Scopus за период с 1970 по 2021 г. Заключение: по данным анализированных работ, карбонат лития может оказывать значительный эффект на патогенез болезни Альцгеймера, что может стать перспективным в разработке терапии этого до сих пор неизлечимого заболевания. Важно также отметить противовирусные эффекты карбоната лития. В исследованиях показано, что он способен смягчать иммунно-воспалительную активацию, наблюдаемую во время эпизодов биполярного расстройства, включая нормализацию уровней цитокинов. Наиболее интересным является прямое воздействие лития карбоната на некоторых членов семейства коронавирусов, что особенно важно в связи с актуальными проблемами, связанными с вирусом SARS-CoV-2, принявшими масштабы всемирного кризиса общественного здравоохранения.
Ключевые слова
нормотимики,
карбонат лития,
нейропротекция,
токсичность,
болезнь Альцгеймера,
коронавирусная инфекция
Об авторах
Ю. А. Сорокина
Приволжский исследовательский медицинский университет
Россия
Россия
Юлия Андреевна Сорокина, кандидат биологических наук, доцент кафедры общей и клинической фармакологии
Нижний Новгород
А. А. Мосина
Приволжский исследовательский медицинский университет
Россия
Россия
Анна Алексеевна Мосина, студент
Нижний Новгород
Ю. М. Пахомова
Приволжский исследовательский медицинский университет
Россия
Россия
Юлия Михайловна Пахомова, магистр нейробиологии
Нижний Новгород
А. В. Занозин
ГБУЗ «Наркологическая больница»
Россия
Россия
Андрей Владимирович Занозин, кандидат медицинских наук, доцент, врач-психиатр
Нижний Новгород
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Рецензия
Для цитирования:
Сорокина Ю.А., Мосина А.А., Пахомова Ю.М., Занозин А.В. Медико-биологические и потенциальные терапевтические аспекты использования препарата лития карбоната. ПСИХИАТРИЯ. 2022;20(2):109-116. https://doi.org/10.30629/2618-6667-2022-20-2-109-116
For citation:
Sorokina Yu.A., Mosina A.A., Pakhomova Yu.M., Zanozin A.V. Biomedical and Potential Therapeutic Aspects of Lithium Carbonate Use. Psikhiatriya. 2022;20(2):109-116. (In Russ.) https://doi.org/10.30629/2618-6667-2022-20-2-109-116
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