Новые пути оптимизации антидепрессивной терапии пожилых депрессивных больных в условиях геронтопсихиатрического стационара

Aim of the study: comparative evaluation of effectiveness and safety of monotherapy with one of the new-generation antidepressants and a complex treatment with the same antidepressants in combination with infusions of Astrox® (ethylmethylhydroxypyridine succinate) in depressive geriatric in-patients. Material and methods: both compared groups included 25 in-patients aged from 60 to 79 years with mild and moderate depression (according to ICD-10) and were treated with mono- or complex (in combination with Astrox®) antidepressant therapy. Treatment effectiveness was assessed with the use of HAM-D, HARS, CGI-S and CGI-I rating scales; cognitive function was assesses with MMSE scale, «Memorizing 10 words» test and clock drawing test.Results: obtained data showed that complex antidepressant treatment in combination with antioxidant medication Astrox® leads to more rapid therapeutic response and significant effectiveness of treatment in comparison with antidepressant monotherapy. The data were confirmed with significant reduction of depression and anxiety rates and improvement of patients’ cognitive function.Conclusion: obtained results allow us to recommend a complex antidepressant treatment of geriatric in-patients in order to reach more rapid and effective treatment response and to shorten hospitalization period.

депрессия, поздний возраст, оптимизация терапии антидепрессантами, Астрокс, depression, elderly in-patients, antidepressants, optimization of antidepressant therapy, Astrox®

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