Нейровизуализация в диагностике депрессивных и аддиктивных расстройств
https://doi.org/10.30629/2618-6667-2017-75-31-38
Abstract
The aim was to study neuroimaging changes of the brain in depression and addictive disorders.Results: research shows that depressive patients with various etiologies have the structural and metabolic differences. Drug- dependent patients have alterations in the structures of the limbic system in which dopamine and opioid receptors localized. These patients have atrophic processes in the brain (cortex thickness have reduced, the amount of gray and white matter lowered in sections that realize the emotional and cognitive functions). New information on the pathogenesis of drug-resistant depression have received by investigators.Conclusion: brain imaging with MRI and DTI are high informative for diagnostics of brain pathology in addiction and for evidences of brain lesion because addictive agents action.
About the Authors
Владислав Шамрей
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Игорь Железняк
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Дмитрий Тарумов
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Евгений Абриталин
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Б. Литвинцев
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Денис Якуша
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
Петр Мананцев
Военно-медицинская академия им. С.М. Кирова
Russian Federation
Russian Federation
References
1. Станжевский А.А., Тютин Л.А., Костеников Н.А. Позитронная эмиссионная томография головного мозга: принципы и методы обработки изображений (обзор литературы). Лучевая диагностика и терапия. 2010;1(2):12-20
2. Hurley R.A. Windows to the brain: insights from neuroimag- ing. In: R.A. Hurley, K.H. Taber. American Psychiatric Publishing, 2008:236
3. Amat J., Baratta M.V., Paul E., Bland S.T., Watkins L.R., Mai- er S.F. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat. Neurosci. 2005;8:365-371
4. Amat J., Paul E., Zarza C., Watkins L.R., Maier S.F. Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial pre- frontal cortex. J. Neurosci. 2006;26:13264-13272. doi: 10.1523/ JNEUROSCI.3630-06.2006
5. Kimbrell T.A., Ketter T.A., George M.S., Little J.T., Benson B.E., Willis M.W., Herscovitch P., Post R.M. Regional cerebral glu- cose utilization in patients with a range of severities of uni- polar depression. Biol. Psychiatry. 2002;51:237-252
6. Maier S.F., Amat J., Baratta M.V., Paul E., Watkins L.R. Behav- ioral control, the medial prefrontal cortex, and resilience. Dialogues Clin. Neurosci. 2006;8(4):397-406. PMID:17290798 PMCID: PMC3181837
7. Koenigs M., Tranel D. Irrational economic decision-making after ventromedial prefrontal damage: evidence from the ultimatum game. J. Neurosci. 2007;27:951-956
8. Mayberg H.S., Lozano A.M., Voon V., McNeely H.E., Semino- wicz D., Hamani C., Schwalb J.M., Kennedy S.H. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45(5):651-660. doi: 10.1016/j.neuron.2005.02.014
9. Mayberg H.S., Brannan S.K., Tekell J.L., Silva J.A., Mahurin R.K., McGinnis S., Jerabek P.A. Regional metabolic effects of fluox- etine in major depression: serial changes and relationship to clinical response Biol. Psychiatry. 2000;48:830-843
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