Clinical and biological approaches to the diagnostics and substantiation of personalized therapy in patients with autism spectrum disorders

The objective of the study was to determine the efficacy of the early prescription of differentiated personalized therapy based on biological data at the moment of the examination of the patient by a psychiatrist to specify the prognosis of the further course of the disease. In this case, the objectivity of the severity of symptoms was carried out on the basis on the laboratory diagnostics using «Neuro-Immuno-Test» and EEG mapping.

Patients and methods: 250 patients aged 3-15 years (mean age &3 years) were examined using psychopathological neuro-immunological and neuro-physiological tests. Criteria of inclusion into the study were as follows: the presence of a psychotic episode (or formation of remission) with a predominance of nosologically non — specific catatonic disorders and cognitive disorders, as well as the lack of social interaction stereotyped behavior and the presence of cognitive deficit in a case of non-psychotiс (evolutionary) forms of ASD; the necessity of pharmacotherapy and informed consent of the parent or guardian of the child to participated the study.

Results and conclusion: the new developed mutidlsdplinaiy method determining the need for the use of psychopharmacotherapy in patients with autism spectrum disorders at the time of their examination in clude clinical examination of patients and nosological definition of the disease according to ICD-10 and DSM-V. The additional neurophysiological examination of bioelectric activity of the patient's brain allows evaluating of separate EEG parameters (predominantly beta and theta rhythms) with specificities of structure of the clinical manifestations. New multidisciplinary method Includes immunological examination of patients with determining of enzymatic activity of leukocyte elastase (LE), functional activity of α₁-proteinase inhibitor (α₁-PI), and the level of auto antibodies to neurospecific antigens S l00b and myelin basic protein (MBP) In peripheral blood serum. Psychopharmacotherapy is prescribed to the patient according to the results of clinical examination with reliable excess of one, or all of the values of the investigated biological Indices in comparison with healthy children of the appropriate age.

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