Long-term follow up of children with high risk of schizophrenia
Abstract
Aim. Description of the age-related dynamics of mental disorders in children at high risk (HWR) for schizophrenia, started at an early age with an assessment of their prognostic significance.
Materials and methods. Cohorts of observation comprised 140 children from parents with schizophrenic disorders, and 50 healthy children collected during the screening of a children's population in one of the districts of Moscow in 1985-1995 were traced prospectively within 10-15 years. Children were examined using clinical and paraclinical methods, including scales GN0M, PANSS, CARS.
The results obtained. According to the severity of the mental state in the first year of life, the cases were divided into cases with separate stigmas of the genetic predisposition to schizophrenia, cases with outpost-symptoms of the affective and neurosislikelevel and outpost-symptoms of the psychotic level. Subsequently, 40 children were diagnosed with RAS, 40 with schizophrenia, and 60 had some symptoms of schizotypal stigmatization. In the 10 to 15-year period most children showed a positive dynamics of mental disorders, only 34,3% of children who had an outpost symptom of mental disorders at an early age had severe autistic disorders or schizophrenia. In the control group all children remained healthy.
Conclusions. Early detection of children with endogenous developmental risk factors creates opportunities for early initiation of preventive measures, and if necessary, adequate therapy.
About the Author
М. A. Kalinina
FSBSI «Mental Health Research Centre»
Russian Federation
Russian Federation
Kalinina Marina - candidate of medical sciences, MD.
Moscow.
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For citations:
Kalinina М.A. Long-term follow up of children with high risk of schizophrenia. Psychiatry (Moscow) (Psikhiatriya). 2018;(78):41-47. (In Russ.)
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