Peculiarities of Negative Personal Changes in Patients with Different Structure of Manic-Paraphrenic States

Background: the study of the pathopsychological features of the mental activity of patients with various types of manic-paraphrenic conditions (MPS) within the endogenous attack-like psychosis. to clarify the severity of negative personality changes and to determine prognostic significance. The obtained data allow us to objectively evaluate the parameters of mental activity and to study the pathopsychological mechanisms of the development of manic-paraphrenic types.

Objective: assess the severity of negative personality changes based on an analysis of the pathopsychological characteristics of mental activity in patients with various typological varieties of manic-paraphrenic syndrome developed in endogenous paroxysmal psychosis. Patients and methods: 42 patients (all women aged from 18 to 50 years) with manic-delusional and manic-paraphrenic attacs in endogenous psychosis (F20.01, F20.02, F25, F31.2 according to ICD-10) were examined with pathopsychological methods. According to the results of the clinical and psychopathological study, 2 typological varieties of MPs were identified: I — with a predominance of acute sensory delirium of perception (13 patients); II — with a predominance of poorly systematized interpretative delirium (19 patients). A group of comparison with manic-delusional states with delusions of grandeur (10 patients) was studied. The results of the study were compared with the relevant indicators in control group of healthy subjects of the same age and sex (50 people).

Results: the clinical and psychological study of patients with different types of manic-paraphrenic syndrome showed significant differences in the quality and pace of changes in mental processes, and in personal characteristics. This reflects a different degree of progression of paroxysmal endogenous psychoses and severity of negative symptoms. Noted heterogeneity significantly depends on the nature and severity of productive disorders, difficult to interact with the characteristics of personal dynamics of patients.

Conclusions: the found correlations of clinical and pathopsychological factors increase the significance of the pathopsychological method in the field of objectifying the study of these disorders and determine the urgent need to incorporate pathopsychological analysis into joint interdisciplinary research.

1. Subbotskaya NV. PsixopatoLogiya ostrogo parafren-nogo sindroma i ego tipologicheskie variant. Psychiatry. 2005;17(5):26-31. (In Russ.).

2. SokoLov AV. PsychopathoLogicaL features and delusion of exaggerated self-esteem in endogenous manic-deLusion states. Zhurnal nevrologii i psihiatrii imeni S.S. Korsakova. 2012;112(2):18-24. (In Russ.).

3. AppeLbaum P, CLark Robbins P, Roth Loren H. DimensionaL Approach to DeLusions: Comparison Across Types and Diagnoses. The American Journal of Psychiatry. 1999;156:1938-1943. https://doi.org/10.1176/ajp.156.12.1938.

4. KnowLes R, McCarthy-Jones S, Rowse G. Grandiose deLusions: A review and theoreticaL integration of cognitive and affective perspectives. Clinical Psychology Review. 2011;31(4):684-696. DOI:https://doi.org/10.1016/j.cpr.2011.02.009.

5. PavLichenko AV. Negative symptoms of schizophrenia: modern foreign concepts and pathophysioLogicaL mechanisms. Psychiatry. 2018;1(77):86-96. (In Russ.).

6. Ivanov MV, Neznanov NG. Negativny'e i kognitivny'e rasstrojstva pri e'ndogenny'x psixozax. SPB:NIPNI im V.M. Bextereva; 2008. (In Russ.).

7. Johannesen J, O'DonneLL B, Shekhar A, et aL. Diagnostic specificity of neurophysioLogicaL endopheno-types in schizophrenia and bipolar disorder. Schizophrenia Bulletin. 2013;39(6):1219-1229. https://doi.:10.1093/schbuL/sbs093.

8. Sizov SV. CLinicaL and PsychopathoLogicaL Differentiation of Endogenous Mank-Paraphrenic States. Psychiatry. 2019;17(3):30-37 (in press). (In Russ.).

9. Kritskaya VP, MeLeshko TK. The pathopsychoLogy of schizophrenia. M.: PubLishing house «Institute of PsychoLogy RAS»; 2015. (In Russ.).

10. MeLeshko TK, Kritskaya VP. To the probLem of specificity of schizophrenic pathoLogy. Psychiatry. 2016;4(72):20-26. (In Russ.).

11. Penn D, Ganna L, Roberts D. SociaL cognition in schizophrenia: an overview. Schiz. Bull. 2008;3(34):408-411.

12. Snezhnevsky AV. Nosos et pathos schizophreniae. In: Schizophrenia, muLtidiscipLinary research. M.; 1972:5-15. (In Russ.).

13. Nadzharov RA. Forms of course. In: Schizophrenia, muLtidiscipLinary research. M.; 1972:16-76. (In Russ.).