The role of anticonvulsants and antidepressants in the treatment of affective and anxiety disorders in patients with epilepsy
https://doi.org/10.30629/2618-6667-2015-67-58-64
Abstract
Background. Epilepsy is associated with the development of a wide range of mental disorders, requiring direct participation of the psychiatrist in their recognition, diagnostics, and therapy. Among all psychopathological disorders affective and anxiety disorders are the most important.The aim of the paper was to present clinical characteristics of depressive and anxiety disorders in epilepsy and to substantiate current psychopharmacology of these impairments. Based on the literature data and our own studies specificities of the affective symptomatology characteristic of epilepsy were demonstrated. Significance of cognitive impairments with impairments of executive functioning was emphasized. Comparison of clinical manifestations of depressive and anxiety disorders was carried out with localization and lateralization of epileptic focus, the leading arm factor, and the presence of alexithymia. The impact of pharmacological mechanisms of action of (GABA-ergic and antiglumatergic) antiepileptic drugs on affective disorders was discussed, as well as possibility of decrease in frequency of seizures and reduction of seizure disorders during treatment with antidepressants from SSRI group.Conclusion was made, emphasizing individualized approach to the choice of antiepileptic and antidepressive drugs for the treatment of patients with epilepsy with affective and anxiety disorders.
About the Author
Vladimir Kalinin
Moscow Scientific Research Institute of Psychiatry, Branch of FSBI «FMRCPN» of Rosminzdrav
Russian Federation
Russian Federation
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For citations:
Kalinin V. The role of anticonvulsants and antidepressants in the treatment of affective and anxiety disorders in patients with epilepsy. Psychiatry (Moscow) (Psikhiatriya). 2015;(3):58-64. (In Russ.) https://doi.org/10.30629/2618-6667-2015-67-58-64
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