Ультраструктурное морфометрическое исследование лимфоцитов у больных шизофренией при лечении оланзапином

Background. Previously we performed the ultrastructural morphometric study of lymphocytes in patients with chronic schiz- ophrenia before treatment and normal controls. We aimed to continue this study of the same patients with schizophrenia under olanzapine treatment to detect the effects of gender and treatment efficacy.Material and methods. We studied lymphocytes in 56 patients with schizophrenia treated 8 weeks with olanzapine and 49 patients treated 28 weeks with olanzapine as compared with 59 patients before treatment and 31 normal controls. Electron microscopy and morphometry were applied to estimate frequency and ultrastructural parameters of small, large, large activated lymphocytes (containing 10 and more mitochondria) and of atypical lymphocytes (lymphoblasts) in men and women, in responders and non-responders.Results. No gender or treatment resistance effects were found in the percentage of small, large and large activated lymphocytes and lymphoblasts in schizophrenia patients treated with olanzapine as compared to the patients before treatment. The volume fraction and the number of mitochondria in small lymphocytes and the number of mitochondria in large lymphocytes decreased significantly only in non-responders. The reduction of the number of mitochondria in large activated lymphocytes and in lymphoblasts was found in men but not in women. Gender significant differences were revealed in large activated lymphocytes after 8 weeks treatment.Conclusion. Treatment resistance and gender differences are associated with the deficit of mitochondria in lymphocytes of schiz- ophrenia patients treated with olanzapine.

шизофрения, оланзапин, лимфоциты, ультраструктура, морфометрия, митохондрии, пол, терапевтическая эффективность, schizophrenia, olanzapine, lymphocytes, ultrastructure, morphometry, mitochondria, gender, treatment efficacy

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