Влияние перемасштабирования шкалы PANSS на оценку эффективности антипсихотической терапии

The aim of study was to investigate the impact of PANSS «rescaling» on a number of statistical indices: reduction of the mean total score, regression coefficients of the mean total score dynamics, the Kaplan-Meier survival curve median and on statistical characteristics of Student‘s t-criterion.Materials and methods. The data, obtained during evaluation of antipsychotic efficacy of Solian (amisulpride), was used in the paper. A total of 46 patients with shift-like (27 patients) (F20.01, F20.02 on ICD-10) and paranoid (19 patients) (F20.0 on ICD-10) courses of schizophrenia received Solian. The duration of treatment made up 56 days. Mental status of patients was assessed on the 1st, 7th, 14th, 21st, 28th, 35th, 42nd, 49th, and 56th days. Clinical dynamics of the mental status of patients, characterized by the mean PANSS total score calculated under conditions of various graduation in comparison groups with shift-like and continuous paranoid courses of schizophrenia, was analyzed in this study. The analysis of the obtained data was performed by using statistical methods.Results. The analysis of impact of PANSS «rescaling» on indices revealed during its statistical processing under conditions of various approaches to ranging was performed. It was demonstrated that the mean PANSS total score reduction coefficient evaluated in S1-7 graduation substantially differed from that in S0-6 graduation. The slope coefficient did not depend upon the scale ranging inregression analysis, and the portion of regressionline, assessed according to S0-6, was smaller than that for S1-7 exactly by 30 points.It was established, that the Kaplan-Meier survival curves depended upon graduation, in which the mean total score was calculated.At the same time the type of graduation used for calculation of the mean total score did not influence the statistical indices, obtained according to Student’s t-criterion. Such results are explained by the type of transformation of initial random quantities: linear transformation of initial variables (coefficient of regression line slope and Student’s statistics) does not depend upon thetype of scale, and nonlinear transformations (reduction coefficient, the Kaplan-Meier survival curves and the portion of regression line) substantially depend upon the type of the used scale.Conclusions. The evaluation of antipsychotic effect of psychotropic medicine, using PANNS scale under conditions of change of its ranging from 1-7 to 0-6, revealed higher results of this efficacy. Ranging of scale from the initial 0 index may be recommended in cases, when it is known that for estimation scale, beginning from point 1, the investigated sign is absent.

шизофрения, лечение, Солиан, шкала PANSS, перемасштабирование, средний суммарный балл, ранжи- рование, schizophrenia, treatment, Solian, PANSS, rescaling, the mean total score, ranging

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