Нейрофизиологический профиль больных шизофренией юношеского возраста с длительностью катамнеза 20-25 лет

Introduction: the study of brain functionality with neurophysiological method is one of the informative approaches to discrimination of additional diagnostic and prognostic markers of the disease. The article summarizes the findings of the initial stage of such investigation.Aims was to determine the neurophysiological profile of youth schizophrenia patients with the long-term follow-up 20-25 years. Methods: background EEG and auditory evoked potentials in oddball paradigm were recorded in 18 patients with youth schizo- phrenia (illness duration more than 20 years) and 10 age and sex matched mentally healthy subjects. Spectral power of theta, alphaand beta1 rhythms and amplitude and latencies of P300 were analyzed.Results and discussion: as compared to controls, the patients had higher spectral power of theta-rhythm but no differences by amplitude or latency of parietal P300. There were no statistically significant correlations between neurophysiological and clinical characteristics. The findings assume that pathological processes in base of tested neurophysiological characteristics are compen- sated at some extent in the patients with long-term follow-up of youth schizophrenia and do not determine the psychopathology at this illness stage.

шизофрения, отдаленный катамнез, фоновая ЭЭГ, вызванные потенциалы в парадигме oddball, тета-ритм, Р300, schizophrenia, long-term follow-up, background EEG, evoked potential in oddball paradigm, theta rhythm, P300

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