Мозаичная анеуплоидия в клетках головного мозга при болезни Альцгеймера: мини-обзор
https://doi.org/10.30629/2618-6667-2016-72-49-54
Аннотация
Об авторах
Юрий Борисович ЮровРоссия
Светлана Григорьевна Ворсанова
Россия
Алексей Дмитриевич Колотий
Россия
Мария Александровна Зеленова
Россия
Иван Юрьевич Юров
Россия
Список литературы
1. Tanzi R.E. The genetics of Alzheimer disease. Cold Spring Harb. Perspect. Med. 2012;2. DOI:10.1101/cshperspect.a006296
2. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Somatic cell ge- nomics of brain disorders: a new opportunity to clarify genetic-environmental interactions. Cytogenet. Genome. Res. 2013;139:181-188. DOI:10.1159/000347053
3. Herrup K. Reimagining Alzheimer’s disease - an age- based hypothesis. J. Neurosci. 2010;30:16755-16762. DOI:10.1523/JNEUROSCI.4521-10.2010
4. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Chromosomal vari- ation in mammalian neuronal cells: known facts and at- tractive hypotheses. Int. Rev. Cytol. 2006;249:143-191. DOI:10.1016/s0074-7696(06)49003-3
5. Mosch B., Morawski M., Mittag A., Lenz D., Tarnok A., Ar- endt T. Aneuploidy and DNA replication in the normal human brain and Alzheimer’s disease. J. Neurosci. 2007;27:6859- 6867. DOI:10.1523/JNEUROSCI.0379-07.2007
6. Iourov I.Y., Vorsanova S.G., Liehr T., Yurov Y.B. Aneuploidy in the normal, Alzheimer’s disease and ataxia-telangiectasia brain: differential expression and pathological meaning. Neu- robiol. Dis. 2009;34:212-220. DOI:10.1016/j.nbd.2009.01.003
7. Arendt T., Mosch B., Morawski M. Neuronal aneuploi- dy in health and disease: a cytomic approach to under- stand the molecular individuality of neurons. Int. J. Mol. Sci. 2009;10:1609-1627. DOI:10.3390/ijms10041609
8. Yurov Y.B., Vorsanova S.G., Iourov I.Y. GIN‘n’CIN hypothe- sis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny. Mol. Cytogenet. 2009;2:23. DOI:10.1186/1755-8166-2-23
9. Yurov Y.B., Vorsanova S.G., Iourov I.Y. Ontogenetic variation of the human genome. Curr. Genomics. 2010;11:420-425. DOI:10.2174/138920210793175958
10. Fischer H.G., Morawski M., Brьckner M.K., Mittag A., Tar- nok A., Arendt T. Changes in neuronal DNA content variation in the human brain during aging. Aging. Cell. 2012;11:628- 633. DOI:10.1111/j.1474-9726.2012.00826.x
11. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Genomic landscape of the Alzheimer’s disease brain: chromosome instabil- ity - aneuploidy, but not tetraploidy - mediates neu- rodegeneration. Neurodegener. Dis. 2011;8(1-2):35-37. DOI:10.1159/000315398
12. Arendt T. Cell cycle activation and aneuploid neurons in Alzheimer’s disease. Mol. Neurobiol. 2012;46:125-135. DOI:10.1007/s12035-012-8262-0
13. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Interphase chromo- somes of the human brain: the biological and clinical mean- ing of neural aneuploidy. In Human Interphase Chromo- somes. Edited by: Yurov Y.B., Vorsanova S.G, Iourov I.Y. New York, Heidelberg, Dordrecht, London: Springer; 2013;53-83. DOI:10.1007/978-1-4614-6558-4_4
14. Russell L.M., Strike P., Browne C.E., Jacobs P.A. X chromosome loss and ageing. Cytogenet. Genome Res. 2007;116:181- 185. DOI:10.1159/000098184
15. Faggioli F., Wang T., Vijg J., Montagna C. Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum. Mol. Genet. 2012;21:5246-5253. DOI:10.1093/hmg/dds375
16. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Single cell genom- ics of the brain: focus on neuronal diversity and neuro- psychiatric diseases. Curr. Genomics. 2012;13:477-488. DOI:10.2174/138920212802510439
17. Potter H. Review and hypothesis: Alzheimer disease and Down syndrome - chromosome 21 nondisjunction may underlie both disorders. Am. J. Hum. Genet. 1991;48:1192-1200
18. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Somatic genome vari- ations in health and disease. Curr. Genomics. 2010;11:387- 396. DOI:10.2174/138920210793176065
19. Arendt T., Brűckner M.K., Mosch B., Lősche A. Selective cell death of hyperploid neurons in Alzheimer’s disease. Am. J. Pathol. 2010;177:15-20. DOI:10.2353/ajpath.2010.090955
20. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Chromosom- al mosaicism goes global. Mol. Cytogenet. 2008;1:26. DOI:10.1186/1755-8166-1-26
21. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Molecular cytoge- netics and cytogenomics of brain diseases. Curr. Genomics. 2008;9:452-465. DOI:10.2174/138920208786241216
22. Bushman D.M., Chun J. The genomically mosaic brain: an- euploidy and more in neural diversity and disease. Semin. Cell. Dev. Biol. 2013;24:357-369. DOI:10.1016/j.sem- cdb.2013.02.003
23. Westra J.W., Barral S., Chun J. A reevaluation of tetra- ploidy in the Alzheimer’s disease brain. Neurodegener. Dis. 2009;6:221-229. DOI:10.1159/000236901
24. Iourov I.Y., Vorsanova S.G., Yurov Y.B. Intercellular ge- nomic (chromosomal) variations resulting in somatic mosaicism: mechanisms and consequences. Curr. Genom- ics. 2006;7:435-446. DOI:10.2174/138920206779116756
25. Yurov Y.B., Vorsanova S.G., Iourov I.Y. The DNA replica- tion stress hypothesis of Alzheimer’s disease. Sci. World J. 2011;11:2602-2612. DOI:10.1100/2011/625690
26. Iourov I.Y., Vorsanova S.G., Liehr T., Kolotii A.D., Yurov Y.B. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain. Hum. Mol. Genet. 2009;18:2656-2669. DOI:10.1093/hmg/ddp207
27. Yurov Y.B., Vorsanova S.G., Liehr T., Kolotii A.D., Iou- rov I.Y. X chromosome X chromosome aneuploidy in the Alzheimer’s disease brain. Mol. Cytogenet. 2014;7(1). DOI:10.1186/1755-8166-7-20
28. van den Bos H., Spierings D.C.J., Taudt A., Bakker B., Porubský D., Falconer E., Novoa C., Halsema N., Kazemier H.G., Hoekstra-Wakker K., Guryev V., den Dunnen W.F.A., Foijer F., Colomé-Tatché M., Boddeke H.W.G.M., Lansdorp P.M. Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons. Genome Biology. 2016;17:116. DOI:10.1186/s13059-016-0976-2
Рецензия
Для цитирования:
Юров Ю.Б., Ворсанова С.Г., Колотий А.Д., Зеленова М.А., Юров И.Ю. Мозаичная анеуплоидия в клетках головного мозга при болезни Альцгеймера: мини-обзор. ПСИХИАТРИЯ. 2016;(72):49-54. https://doi.org/10.30629/2618-6667-2016-72-49-54