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Психиатрия

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Лобно-височная деменция

https://doi.org/2618-6667-2018-77-60-85

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Аннотация

Цель работы: представить анализ современных научных публикаций по проблеме лобно-височной деменции (ЛВД). Материал и методы: по ключевым словам «лобно-височная деменция», «лобно-височная лобарная дегенерация» в научных базах PubMed, MEDLINE и других отобраны и проанализированы публикации за последние два десятилетия. Результаты: к настоящему времени в наиболее разработанном виде в литературе представлены феноменология и диагностические критерии основных типов ЛВД. Прогресс в распознавании заболевания, его отдельных типов основан на результатах изучения диагностической значимости современных методов нейровизуализации. ЛВД признается одной из ведущих причин раннего начала деменции, однако распространенность ЛВД в популяции старших возрастных групп изучена недостаточно. Успехи молекулярно-генетических исследований ЛВД определяют направления дальнейшего изучения патогенеза заболевания и совершенствования его систематики. Обоснована перспективность изучения отдельных факторов риска и их комбинаций в качестве актуальной задачи дальнейших клинических и популяционных исследований. Рассмотрены результаты симптоматической терапии с применением мемантина для лечения деменции и СИОЗС для коррекции поведенческих расстройств. Вывод: совершенствование систематики ЛВД и достижения нейронаук создают перспективы разработки эффективных методов симптоматической психофармакотерапии (мемантин, СИОЗС) и нозомодифицирующего терапевтического вмешательства с применением генных технологий.

Об авторе

Яна Борисовна Федорова
ФГБНУ «Научный центр психического здоровья», Москва
Россия
кандидат медицинских наук, старший научный сотрудник


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Для цитирования:


Федорова Я.Б. Лобно-височная деменция. Психиатрия. 2018;1(77):60-85. https://doi.org/2618-6667-2018-77-60-85

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Fedorova Y. Frontotemporal dementia. Psychiatry. 2018;1(77):60-85. (In Russ.) https://doi.org/2618-6667-2018-77-60-85

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