Abnormalities of oligodendrocyte clusters in the inferior parietal cortex in schizophrenia: effect of age at onset

Background and Objectives. The inferior parietal and the prefrontal cortex are an essential part of the heteromodal associative cortex involved in the pathophysiology of schizophrenia. Neuroimaging studies demonstrated that abnormalities in the parietal cortex in schizophrenia are associated with early onset of disease that coincides with a key time point in myelination. The deficits of oligodendrocytes have been reported in the prefrontal cortex in schizophrenia.Methods. The morphometric study of the numerical density of oligodendrocytes and oligodendrocyte clusters was performed in the inferior parietal cortex (layer 3 of Brodmann’s area 40) in the normal controls and in the schizophrenia subjects. The autopsy section collection from the Stanley Medical Research Institute (USA) and optical disector method were used for the study.Results. No significant group difference was found in the numerical density of oligodendrocytes. However, the numerical density of oligodendrocyte clusters was 30% lower in the schizophrenia group compared to the control group ( p < 0,01). A significant deficit in the numerical density of oligodendrocyte clusters (- 40%, p < 0,01) was revealed only in the subgroup with early onset of disease (9-18 y.о.) as compared to the controls.Conclusions. The data suggests that the deficit of oligodendrocyte clusters might be associated with altered proliferation and/ or maturation of oligodendrocyte progenitors in schizophrenia.

шизофрения, нижняя теменная доля, морфометрия, олигодендроциты, кластеры олигодендроцитов, возраст начала заболевания, schizophrenia, inferior parietal lobule, morphometry, oligodendrocytes, oligodendrocyte clusters, age at onset

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