Mild cognitive impairment (MCI) gets more scientific and practical significant due to relevance of cognitive research in normal and abnormal aging.The aim was to present an analisis of russian and foreign neuropsychological methods of MCI assessment.Material. The first fragment consists introductory, description of Russian neuropsychological research of MCI, main approaches to the quantitative study of MCI and essential requirements to methods of cognitive evaluation in MCI.Conclusion. Neuropsychological assessment of MCI is necessary component of complex clinical and psychological diagnostics in aged.

The authors review the paper of А. Sekar et al. (2016) that has provided the first evidence for the link between gene variations reported earlier in the GWAS of schizophrenia and the biological process involved in the etiology of this disease.

The aim of the study is to analyze literature data on the Tiapridal treatment of dementia patients with behavioral and psychotic disorders.Material and method. The literature review is based on the assessment of the effectiveness and safety of Tiapridal used in the treatment of dementia with behavioral and psychotic disorders. This review describes the clinical characteristics of behavioral and psychotic disorders in patients with dementia. In this paper we analyzed modern approaches to pharmacological correction of these disorders. Alarge number of both preclinical and clinical studies on the application of Tiapridal in the world medical practice was described in this review.Conclusion. The analysis of the studies demonstrates the high efficiency and broad spectrum of Tiapridal treatment.

Background. The rates of child and adolescent suicide in the Russian Federation since the 1990s are among the highest in the world; there are enormous differences across the Russian regions.The aim was to study registered psychiatric morbidity in the Russian Federal subjects from 2005 to 2013 and the relation of registered morbidity to the prevalence of child and youth suicide.Material and methods. Official record data on psychiatric morbidity and suicide mortality for children and adolescents in subjects of the Russian Federation has been analysed.Results. The paper presents statistical analysis of the time trends in registered psychiatric morbidity in the Russian Federal subjects from 2005 to 2013 and the relation of registered morbidity to the prevalence of child and youth suicide. In children, registered psychiatric morbidity progressively decreased from 2005 to 2013; in adolescents, both primary and general morbidity increased from 2005 and decreased from 2009. There was statistically significant decrease in child and youth suicide rates from 2011 to 2013. Regional factor explained around 67% of the variance in registered morbidity and suicide rates across the Federal subjects. In regions with different suicide rates, registered morbidity significantly differed; in ten most disadvantaged regions high suicide rates were associated with low registered psychiatric morbidity.Conclusion. The study findings provide a strong case for the development of child and adolescent mental health services; an associated increase in registered psychiatric morbidity in the disadvantaged regions should not be considered a negative feature.

Objective: to establish the psychopathological profile of syndrome of overvalued ideas formed within the framework of the episode of endogenous depression.Material and methods: 52 patients (30 women, 22 men; mean age 36,4 ± 6,7 years) with endogenous depression with the syndrome of overvalued ideas, surveyed using clinical-psychopathological method, standardized assessment (Hamilton scale).Results Three typological groups were highlighted based on the analysis of the psychopathological features of the syndrome of overvalued ideas in the structure of endogenous depression: affect-affiliated, affect-dissociated and affect-distant mechanism.

Aim. To compare levels of brain isoform creatine phosphokinase (CPK BB) in autopsied anterior and posterior cingulate cortex from patients with schizophrenia and control subjects.Methods. Extracts of readily soluble and membrane-associated proteins were prepared from autopsied samples of anterior (Brodmann area 24) and posterior (Brodmann area 23) cingulate cortex from patients with schizophrenia ( n = 15) and from control group ( n = 14), the samples were matched by age and postmortem interval. CPK enzymatic activity was measured by determination of nonorganic phosphate, amounts of immunoreactive CPK В were estimated by ECL-Western blotting using monoclonal antibodies.Results. Significant decrease in CPK activity and amounts of immunoreactive CPK В was observed in fractions of readily soluble proteins in cingulate cortex of patients with schizophrenia compared with controls ( p < 0,01). No significant difference in CPK activity and amount of CPK B was found in membrane-associated protein fractions from cingulate cortex (areas 23 and 24) of patients with schizophrenia and controls.Conclusion. Significantly reduced level of the central energy metabolism enzyme (brain CPK BB) indicates the significant impairment of energy metabolism in cingulate cortex of patients with schizophrenia and represents important aspect of schizophrenia pathogenesis.

The aim was to develop conceptual and methodological background of skills training for psychoemotional and psychophysical self-regulation in patients with schizophrenia, to describe the results of its implementation in practice.Materials. The training was introduced to the work of the psychiatric hospital № 14, Moscow. The training was attended by 24 patients suffering from paranoid and sluggishly progressing schizophrenia. The mental state in remission characterized with disorders of astenic, astenic-depressive and anxiety spectrum.Results. The article describes the organizational and methodological approaches, objectives, structure and stages of training to develop the skills of psychophysical and psychological and emotional self-regulation in patients with schizophrenia, the results of the meetings. The conceptual framework of the training is based on the integration of the ideas of a number of theoretical approaches, among which are the theory of social learning, cognitive-behavioral therapy, body-oriented psychotherapy, educational kinesiology. Analysis of the implementation of the training into practice shown the development skills of breathing control and psychoemotional state decreases anxiety, reduces muscle tension, and improves the coordination of movements, intensifies energy resources of the body in patients with schizophrenia.Conclusion. The inclusion of training in a complex therapeutical intervention is useful for optimization of psychosocial rehabilitation of patients with schizophrenia.

Background. The use of modern long-lasting forms of antipsychotics is one of the rational approaches to improvement of compliance of patients with schizophrenia and efficacy of treatment.The aim of the study: was to evaluate clinical and economic efficacy of Rispolept Consta in treatment of schizophrenia patients under conditions of routine out-patient clinical practice.Material and Methods. The efficacy of Rispolept Consta prescription to patients with schizophrenia in the practice of work of psychoneurological dispensary (PND) was investigated in observational study. 29 patients with schizophrenia received Rispolept Consta during a year. Economic efficacy was estimated by comparing the frequency and duration of institutionalizations in mental hospital, out-patient treatment, out-patient cessation of exacerbations, and emergency calls during the year of treatment with Rispolept Consta with preceding period of therapy of the same duration.Results. Significant reduction of frequency and duration of hospitalizations, relapses, suicides, episodes of aggression, reduction in expenditures for treatment was shown. Improvement in compliance of patients was noticed, as well as achievement of regular PND attendance, improvement of labor activity of patients, change in the structure of concomitant therapy towards reduction in the number of drugs from other groups.Conclusion. Long-term treatment with Rispolept Consta in everyday practice contributes to clinical improvement of mental status of schizophrenia patients, their functional rehabilitation and resource saving in the system of mental health services.

The actuality of the given problem was shown, based on the analysis of the literature data, concerning the influence of religiosity of patients on the efficacy of treatment and rehabilitation work with patients suffering medical and psychic pathology.The aim of the study was to choose the target of psychocorrectional work, to develop, and apply religious coping strategies in rehabilitation of patients with shift-like schizophrenia at the stage of remission.Material and methods. The study was carried out in 2 stages. At the first stage comparative analysis of value-oriented semantic structures/value-semantic structures of personalities in patients with religious and non-religious world outlook was performed in comparison with corresponding groups of the healthy controls.Results. Specificities of value-oriented semantic structures/value-semantic structures were revealed, on the basis of which development and application in practice of religiously oriented coping strategies were conducted at the second stage of the study. Directions of psychocorrectional, individual, and group psychotherapy were developed, carried out both under conditions of out- patient practice, and inlong-term stay rehabilitation camps, which alongside with obligatory psychopharmacological therapy made it possible to achieve better compliance of patients, better quality of remissions, and improvement of life quality.

Background. Religious manifestations of mentally disordered individuals seem to be regarded as some «refracted» common peculiarities of mentally normal believers.The objective was to describe general psychological features of religious personality significant for rehabilitation of mental patients.Material and methods. Some psychological peculiarities of the religious personality are regarded compared with normal manifestations of religiosity from those patients whose mental disorder is grounded in religion. The article defines religiosity as an extent of the actualization of person’s psychologically real relationship with transcendent Supreme Being.Results. Some psychological peculiarities of the religious personality are presented, such as: the dual representations of reality in a consciousness, the presence of the spiritual level of meaning structures, the duality of self-awareness that combines divine and wordly meanings and value orientations. Shown that the dominant motivation of religious conversion is person’s seeking the support and con- solation in various types of religiosity. The main forms of religiosity are described concerning the communication, cognition, activity.Conclusion. It is important for the rehabilitation process (in methodical aspect) to distinguish mentally disordered individuals having relationally normal manifestations of religiosity from those patients whose mental disorder is grounded in religion.